Silicon: Benefits, Dosage, Contraindications

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Silicon is a non-metallic element with an atomic weight of 28. Silicon derivatives are slightly soluble. Their solubility is linked to the abundance of Si - OH groups and their accessibility outside the molecule. Silicon is very abundant in nature, being the second element after oxygen, representing 28% of the Earth's crust. It is found abundantly in the mineral world, where it plays an essential structural role (like carbon in organic matter). It is also found in plants and animals where it occupies a secondary place, most often related to structure or protection. In humans, the fixation of silicon by the body begins as early as the fetal life in the brain, muscles, and spleen, before diversifying to other organs. The adult body contains in total about 7 grams of silicon, placing it, like iron (4 grams), between minerals (sodium, potassium, calcium, magnesium, phosphorus) and trace elements. Silicon exists in mineral form (silicic acid) and organic form, incorporated in macromolecules. In the blood, about 5 mg/l is found, mostly in free form, not bound to proteins. Its distribution is uneven in tissues. It is abundant in: - Connective tissue that ensures junction, support, and flexibility, - Cartilage tissue, - Skin and appendages, - Lymphoid tissue, - Lungs and adrenal glands. It is mainly found in growth and regeneration areas. Silicon is present in tap water, some spring, and mineral waters, cereals, seeds, and beer. The presence of silicon is necessary for biosynthesis of certain molecules such as collagen, elastin, and hyaluronic acid and thus influences all tissues where these substances play an important role: connective tissue in general, and more particularly the cartilage, bones, skin, and immune system.

Other name(s) 

Orthosilicic Acid, Silica

Scientific name(s)

Silicon, Si

Family or group: 

Minerals and Trace Elements


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Osteoporosis
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Premenopausal men and women with higher dietary silicon intake seem to have higher bone mineral density, which could reduce the risk of osteoporosis. Another clinical study suggests that a higher silicon intake increases bone mineral density in postmenopausal women under hormone replacement therapy (HRT). This effect has not been observed in women not on HRT. Bone loss in postmenopausal women is mainly due to bone resorption. Silicon seems to affect only bone formation.

Posologie

posologieOrally

posologie40 mg


Wrinkles
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A small preliminary clinical study on healthy volunteers aged 40 to 60 shows that taking a specific product containing 600 mg of organic silicon in hydrolyzed marine collagen once a day for 90 days improves firmness, hydration, and skin texture, but not wrinkles, brightness, or smoothness, compared to placebo.

Posologie

posologieOrally

posologie600 mg


Synergies


Joint Pain
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Silicon is suggested for relieving rheumatism (osteoarthritis). In a multicenter, randomized double-blind study, choline-stabilized orthosilicic acid showed symptomatic improvement in men, but not women, after 12 weeks of supplementation, which was associated with a slight but significant reduction in biomarkers related to cartilage degradation.

Posologie

posologieOrally

posologie5 mg


Hair Beauty
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Silicon helps maintain hair, nail, and/or skin health. Additionally, arterial walls contain large amounts of collagen and elastin synthesized by fibroblasts. Silicon is involved in the synthesis and arrangement of elastin fibers, collagen, and mucopolysaccharides and it is therefore essential.

Posologie

posologieOrally

posologie10 mg


Skin Health
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Silicon helps maintain the health of hair, nails, and/or skin. Silicon concentrates in the skin and even more in nails, fur, and hair. It contributes to the strength and high resistance of keratinized tissues.

Posologie

posologieOrally

posologie10 mg


Synergies


Properties


Bone Density

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In animal research, a silicon deficiency led to significant structural abnormalities of the skull and long bones, strongly suggesting that silicon is necessary for normal bone development. Human research has shown that increased dietary intake of silicon is associated with increased bone mineral density in premenopausal men and women. Other human studies have demonstrated an association between silicon intake and trabecular bone volume and bone mineral density (BMD) in osteoporotic subjects and between markers of bone formation and BMD in women with low bone mass. Orthosilicic acid appears to stimulate osteoblasts in humans. In vitro research suggests that the mechanism of action of silicon includes stimulation of collagen synthesis and other molecules associated with extracellular matrix formation.

Usages associés

Osteoporosis, Joint Pain

Dermatological Effect

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Silicon enables the formation of collagen, elastin, and structural glycoproteins. It induces or regulates fibroblast multiplication and promotes the formation of fibrous proteins (mainly represented by collagen and elastin). These fibers are responsible for the suppleness and elasticity of connective tissue. Silicon concentrates in the skin and even more in nails, fur, and hair. It contributes to the strength and high resistance of keratinized tissues. Low levels have been observed when keratinization is incomplete (Psoriasis, exfoliative dermatosis) and high levels in case of hyperkeratinization. Furthermore, skin aging is correlated with a decrease in silicon. Silicon also prevents hair loss and in some cases, promotes regrowth.

Usages associés

Wrinkles, Hair Beauty, Skin Health

Anti-aging

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Several factors intervene in the aging process including the degeneration of the functional matrix (connective tissue). Indeed, the extracellular matrix composed of collagen and elastin fibers, as well as glycosaminoglycans confer mechanical properties to these tissues and also regulate metabolic activity. Silicon plays a role in the metabolism of collagen, elastin, and glycosaminoglycans, so its deficiency promotes aging at the skin, joint (with an osteoarthritis phenomenon), and bone levels (with a tendency to osteoporosis).


Purifying

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Silicon compounds play an important protective role in the body, increasing its self-defense functions and detoxification abilities. This is partly due to the fact that silicon compounds facilitate the elimination of metabolites, foreign and toxic derivatives through urine, and serve as a barrier, slowing down degenerative processes and intensifying collagen biosynthesis.


Safety dosage

Adult: 20 mg - 50 mg

The EFSA (European Food Safety Authority) gave a favorable scientific opinion in January 2009 on "orthosilicic acid, stabilized with choline for nutritional purposes in food supplements." The scientific panel determined that the silicon element is perfectly bioavailable from orthosilicic acid stabilized with choline and that its use in food supplements poses no toxicological issues. To date, no Recommended Nutrient Intake (RNI) has been established in Europe. However, "the EFSA estimated that the typical dietary intake of silicon is 20-50 mg/day, which corresponds to 0.3-0.8 mg of silicon/kg body weight per day for a 60 kg person, and concluded that it is unlikely that these intakes cause harmful effects." According to silicon toxicity studies, the lethal dose is above 5 g/kg of body weight, which is more than 1000 times higher than the useful dose for our body.


Precautions

Pregnant woman: avoid

There is not enough reliable information available on the safety of silicon when used in medicinal amounts.

Breastfeeding woman: avoid

There is not enough reliable information available on the safety of silicon when used in medicinal amounts.