L-Ornithine: benefits, dosage, contraindications
Other name(s)
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Amino acids
Indications
Rating methodology
EFSA approval.
Sports Performance ✪✪✪✪✪
The efficacy of ornithine on sports performance is studied with promising results. A study on healthy volunteers indicates that taking 1 g of ornithine hydrochloride twice daily for 7 days, followed by 3 g before a cycling test, reduced fatigue compared to a placebo. Other studies show that a single dose of 0.1 g/kg can increase peak speed in cycling among active young men without affecting exercise duration or maximum oxygen consumption. Additionally, in young weightlifters, daily intake of 1 g of ornithine with 1 g of arginine for 30 to 35 days increased lean body mass, strength, and peak anaerobic power compared to placebo.
Posologie
Synergies
Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males
L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism
The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise
Dry Skin ✪✪✪✪✪
Although ornithine did not improve skin hydration in a small study on adults with dry skin, daily intake of a drink containing ornithine showed an improvement in skin elasticity and a reduction in water loss compared to placebo. Ornithine may help improve skin elasticity and reduce water loss, likely by supporting collagen synthesis and enhancing the skin's barrier functions. Indeed, ornithine is a precursor in the synthesis of polyamine and proline, which are necessary for collagen synthesis and wound repair.
Posologie
Synergies
Properties
Musculoskeletal effects
Ornithine is studied for its potential to enhance athletic performance by increasing muscle mass. It acts as an arginine precursor, involved in protein synthesis, and could stimulate the production of growth hormone and insulin-like growth factor (IGF-1).
Usages associés
Neurological
Preliminary clinical research indicates that ornithine might improve sleep quality and help regulate the circadian clock. A study showed that daily intake of 400 mg of ornithine for 28 days improved wakefulness sensations and increased sleep duration in healthy workers.
Mood effect
Studies suggest that ornithine could improve mood by reducing the cortisol/DHEA-S ratio, an essential hormonal balance for emotional well-being. This may help attenuate stress and promote a general feeling of relaxation.
Safety dosage
Adult from 18 year(s): 500 mg - 3000 mg
Ornithine hydrochloride has been used safely at doses up to 500 mg per day for 8 weeks and at doses up to 12 g per day for 4 weeks.