Best Coenzyme Q10: A Pharmacist’s Guide (2025)

We analyzed 9 products sold online and selected Dynveo laboratory’s Coenzyme Q10.

Our selection criteria

• Dosage: amount of active ingredient in a daily dose recommended by the brand. Between 100 and 300 mg per day is recommended.
• Bioavailability: the assimilation of the active ingredient by the body depends on bioavailability. This, in particular, depends on the form of the dietary supplement.
• Origin: it can be synthetic or natural.
• Price / day : this is the price per day for the course at the daily dose recommended by the brand.
• Customer reviews : these customer reviews of the product are collected from the brand’s website or from Amazon.
• Our opinion on the brand : based on the dietary supplement brand tests we carry out every month.

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OUR CHOICE

Dynveo laboratory’s Coenzyme Q10 supplement is, in our opinion, the best on the market.

High-quality coenzyme Q10 is present here in its bioactive form: ubiquinol. It is derived from bio-fermentation rather than chemical synthesis like many other similar supplements.

It is protected from oxidation and is highly bioavailable thanks to a natural micro-encapsulation technology.

The ubiquinol used by the laboratory is 100% pure and patented by the Japanese company Kaneka™.

Dynveo is a dietary supplement laboratory recognized for its expertise and for the dosage of its products. We tested and approved its customer service, responsive and helpful (read our full review here to learn more).

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Quels sont les bienfaits de la coenzyme Q10 ? 

Energy production 

With age, our body’s energy levels decline, and fatigue takes over.

Cardiovascular, respiratory, and physical activities deteriorate. The body becomes more susceptible to oxidative stress, which leads to premature aging. 

Coenzyme Q10 (or ubiquinone) is an antioxidant, meaning that it protects our body from damage caused by free radicals (oxidative stress).

It is found throughout the body, notably in the mitochondria, the small energy factories within our cells. It is essential for energy production. 

Thus, several studies indicate that supplementation with coenzyme Q10 helps relieve fatigue present in certain conditions such as fibromyalgia. 

Furthermore, data suggest that coenzyme Q10 may have beneficial effects on muscular energy production, thereby improving athletic performance in patients with pulmonary disorders after 8 weeks of supplementation. 

Anti-aging action 

As shown by this review, the bioenergetic and antioxidant properties of coenzyme Q10 play a significant role in preventing the onset of age-related diseases. 

The effects of supplementation are the subject of considerable research. One of these studies suggests that coenzyme Q10 could be a complementary treatment for the leading causes of death worldwide (diabetes, hypertension, cancer, heart and neurological diseases). 

According to this study in the journal Frontiers in Physiology, supplementation with coenzyme Q10 could help combat the progression of degenerative diseases such as Parkinson’s disease or Huntington’s disease by slowing the decline of cognitive functions, and improve quality of life. Further studies are needed to confirm this hypothesis. 

In the cosmetics field, its usefulness is also well known in anti-aging skincare.

Indeed, from the age of 25, the level of coenzyme Q10 tends to decrease throughout the body, particularly in the skin, causing the appearance of the first wrinkles.

Concentrated coenzyme Q10 products have, in addition to their antioxidant properties, a noteworthy moisturizing effect.

Anti-inflammatory action 

Several studies have proven the anti-inflammatory effects of Coenzyme Q10. Supplementation over a period ranging from one week to four months resulted in a significant reduction in cytokine production. These molecules drive systemic inflammation. 

Similarly, an experimental trial showed that the production of pro-inflammatory substances in patients with chronic inflammatory diseases (rheumatoid arthritis) is significantly reduced after supplementation. 

Finally, a randomized trial (a protocol in which a treatment is compared to a placebo) shows that taking Coenzyme Q10 for 40 days relieves chronic pain and anxiety, and reduces inflammation in patients suffering from fibromyalgia. 

It may also be effective as a complementary treatment for migraine, thanks to its anti-inflammatory and antioxidant properties. 

Indeed, mitochondrial dysfunction and oxidative stress are among the many causes that can be responsible for a migraine. A meta-analysis reports that using Coenzyme Q10 as a therapeutic agent is promising to reduce the duration and frequency of migraines. 

Cardiovascular action 

In patients with heart failure, there is a coenzyme Q10 deficiency. 

A study confirmed that supplementation with coenzyme Q10 contributes to improved cardiac function.

Another reveals that it reduces the risk of recurrence and sequelae of myocardial infarction.  

Finally, it promotes a balanced blood pressure. A meta-analysis shows that taking it lowers blood pressure, without notable adverse effects. 

Quelles sont les sources alimentaires de coenzyme Q10 ? 

External intake of coenzyme Q10 can be provided by oils, notably canola oil, and by meats (pork, beef, and chicken).

Fatty fish (trout, sardines, herring) and nuts (peanuts, pistachios) also contain it.

In lower concentrations, it is also found in broccoli, an excellent antioxidant food. It is also found in cauliflower, raspberries, oranges, eggs, and soy. 

Sous quelle forme la choisir ? 

In softgel capsules 

Regardless of the form of coenzyme Q10 used, this compound is liposoluble. It is therefore better absorbed when taken with a fatty meal. 

This is why laboratories generally offer it in the form of a softgel capsule, which contains the active substance mixed with oils or fatty acids. 

The body thus absorbs it optimally, as shown by this study. 

In capsules 

The capsules contain coenzyme Q10 powder. This form is not the most bioavailable, but it remains adequate. It has the advantage of containing fewer preservatives and chemical agents than other packaging. 

In liquid form 

The liquid form consists of microparticles containing coenzyme Q10. This form is more expensive and is more effective when the dietary supplement is of good quality!

The stability of the product depends on the manufacturing process used by the laboratory. 

Quels sont les critères à prendre en compte ? 

1. Different forms of Coenzyme Q10 

The production of coenzyme Q10 decreases with age, and its absorption in the intestines remains low, which is why the chosen form is important. 

It exists in three oxidation states: the reduced form, called ubiquinol, the oxidized form called ubiquinone, and an intermediate form not used therapeutically: the ubisemiquinone form.  

These are the ubiquinol and ubiquinone forms that are available on the dietary supplement market.

In humans, although 90% of Coenzyme Q10 is found in its reduced form ubiquinol, both forms are biologically active.  

Studies seem to show that ubiquinol is more effective than ubiquinone in certain processes, notably in energy production and cell growth.

The bioavailability of ubiquinol is higher, and it remains in the body longer than ubiquinone. It is therefore the most active form and should be preferred. 

Another form called the liposomal form has been developed, manufactured using nanotechnology. This type of coenzyme Q10 resists digestive enzymes and thus allows better absorption.

However, few studies exist on the safety of these compounds, so I recommend choosing reputable manufacturers if you opt for a liposomal form. 

2. Manufacturing method 

It is extracted in different ways. Either by fermentation of sugarcane or sugar beet using yeast strains, by bacterial fermentation, or by a chemical process. 

The natural process yields a biologically active coenzyme Q10, and it’s the form most commonly found in dietary supplements.  

The synthetic process involves chemical agents, and coenzyme Q10 is generally obtained from derivatives of tobacco waste. It’s cheaper to produce, but its absorption is not optimal.  

You will find the manufacturing methods on the back of the boxes or on the manufacturer’s website. If there is no specific information, contact the manufacturer or move on!  

3. Product purity 

During the manufacturing process of a dietary supplement, the addition of substances affects absorption. 

Many dietary supplements contain preservatives and additives (notably softgels) to stabilize the mixture between the coenzyme Q10 powder and the oils.

A study reports a reduction in its absorption with the addition of other antioxidants (such as vitamin C) in the dietary supplement’s formulation. 

Capsules generally contain fewer excipients; nevertheless, I advise you to always check the list of ingredients on the back of the box. 

Although production by a natural fermentation process does not involve chemicals, coenzyme Q10 is not yet certified organic. 

4. Dosage of Coenzyme Q10 

The recommended dosage ranges from 100 to 300 mg per day: check whether you are getting at least the minimum of this daily dose with the dietary supplement. 

For a cardiovascular indication, the daily dose should be a maximum of 200 mg, and to reduce fatigue or optimize performance, the dose can increase up to 300 mg. 

For other conditions, the intake can rise up to 1200 mg with a doctor’s approval.

In case of diabetes, regularly monitor your blood sugar during coenzyme Q10 supplementation, because this molecule can improve blood glucose levels.

To summarize

To make sure you choose a high-quality coenzyme Q10, check:

1. Form : choose ubiquinol, the most active form ;
2. Manufacturing method : prefer a natural manufacturing process (fermentation) ;
3. Product purity : check the list of ingredients ;
4. Dosage : It ranges from 100 to 300 mg / day depending on the indications

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OUR CHOICE

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