Tolerase® G: benefits, dosage, contraindications

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Tolerase® G, a proline-specific endopeptidase or prolyl-oligopeptidase, is a food enzyme that has been scientifically shown to help break down gluten in the stomach. Tolerase® G - or Aspergillus niger prolyl endopeptidase - is derived from the food-grade fungus Aspergillus niger. It is marketed by DSM.nnTolerase® G is intended for gluten intolerances, it specifically degrades the immunogenic portions of gluten proteins, and it is stable and active under gastric conditions.nn

Other name(s) 

Aspergillus niger prolyl endopeptidase

Scientific name(s)

prolyl-oligopeptidase

Family or group: 

Enzymes

Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.

Gluten intolerance
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The enzyme that is capable of completely breaking down all epitopes of gluten (gliadin and glutenin), both in the stomach and in the small intestine. Tolerase®-G has optimal activity at a pH of 4-5 and remains stable at a pH of 2. The enzyme is fully resistant to pepsin in gastric juice.nn

Posologie

posologieOral administration

posologie40 PPU

A randomized, double-blind, crossover trial to evaluate bread in which gluten has been pre-digested by prolyl endoprotease treatment, in subjects self-reporting benefits from adopting a gluten-free or low-gluten diet
Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease
Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for celiac disease
Randomized clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers

Properties

Safe dosage

Adult: 40 PPU - 120 PPU

EFSA: Tolerase® G is intended to be consumed just before, during, or immediately after a meal. The recommended dose is 40 PPU of Tolerase® G per meal (= 0.916 g of enzyme preparation) and a maximum daily intake of 120 PPU (2x10E6 PPI) of Tolerase® G (approximately 2.7 g of enzyme preparation), which would correspond to three intakes (three meals) per day.

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The information presented does not in any way replace medical treatment or the advice of a healthcare professional. Before taking any supplements, consult a healthcare professional, especially if you have a medical condition, are undergoing treatment, or are pregnant.