Lipase (digestive enzyme): benefits, dosage, contraindications
Mis à jour le
Lipase is a digestive enzyme that breaks down triglycerides. It comprises a group of enzymes found in animals and plants. Acid-resistant lipase is used as a dietary supplement. This fact sheet refers to supplements that contain only lipase from non-pancreatic sources. Pancreatic sources of lipase also contain other digestive enzymes.
Lipase is a widely distributed digestive enzyme in the plant world and is also found in milk, dairy products, bacteria, molds, and animal tissues. Castor seeds and hulled oats are also plant sources of acid-stable lipases. Lipase aids the digestion of fats by hydrolyzing triglycerides in the stomach and small intestine. Lipase supplements are destroyed by gastric acid.
When taken orally, lipase is used for dyspepsia, heartburn, celiac disease, inflammatory bowel disease (IBD) and cystic fibrosis. It is also used in pasteurized breast milk or infant formula for premature infants.
Family or group:
Enzymes
Indications
Scoring methodology
EFSA approval.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.
Digestive disorders ✪✪✪✪✪
A small clinical trial shows that taking a specific acid-resistant lipase at a dose of 280 mg immediately before a high-fat meal reduces postprandial bloating and nausea compared with placebo in people with postprandial distress syndrome.
Posologie
By mouth
280 mg
