2'-fucosyllactose: benefits, dosage, contraindications
Other name(s)
2'-FL, FUT2
Scientific name(s)
2'-fucosyllactose
Family or group:
Carbohydrates
Indications
Scoring methodology
EFSA approval.
Child development ✪✪✪✪✪
The use of 2'-Fucosyllactose in infant nutrition is essential for the optimal development of infants. By consuming it, babies benefit from a natural prebiotic that promotes the growth of beneficial bacteria in their gut. This can help reduce digestive problems, colic, and intestinal infections in infants. In addition, 2'-Fucosyllactose has been shown to also improve infants' immune health, thereby strengthening their resistance to infections.
Posologie
Oral administration
1.2 g/L
powder
Fucosylated oligosaccharides of human milk protect suckling mice from heat-stabile enterotoxin of Escherichia coli
Recent advances on 2'-fucosyllactose: physiological properties, applications, and production approaches
Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition
Human milk glycans protect infants against enteric pathogens
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Digestive disorders ✪✪✪✪✪
It has been reported that 2'-Fucosyllactose can significantly reduce the incidence of diarrhea in breastfed infants. Furthermore, infants breastfed with milk containing 2-FL have larger populations of bifidobacteria than infants fed milk lacking 2-FL. In adults, this prebiotic helps support a healthy, balanced gut flora, which improves digestion, nutrient absorption, and strengthens the immune system.
Posologie
Oral
0.75 g
powder
Fucosylated oligosaccharides of human milk protect suckling mice from heat-stabile enterotoxin of Escherichia coli
Recent advances on 2'-fucosyllactose: physiological properties, applications, and production approaches
Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition
Human milk glycans protect infants against enteric pathogens
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Intestinal permeability ✪✪✪✪✪
2'-Fucosyllactose (2'-FL) acts against intestinal permeability mainly in two ways. First, 2'-FL can inhibit the attachment of pathogens to the intestinal wall. By binding to pathogen receptors, 2'-FL prevents their adhesion to intestinal epithelial cells, thereby reducing the risk of injury and inflammation. Second, 2'-FL stimulates the production of intestinal barrier-strengthening factors. Bifidobacteria, promoted by 2'-FL, can strengthen the intestinal barrier by improving the integrity of tight junctions between intestinal epithelial cells.
Posologie
Oral
0.75 g
powder
Properties
Digestive effect
2-FL is one of the simplest fucosylated oligosaccharides, meeting all the criteria and acting as a prebiotic to selectively stimulate the growth of beneficial bacteria. A prebiotic is defined as a non-digestible food ingredient that has a beneficial effect on the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, thereby improving the host's health.rnrn
Usages associés
Antimicrobial
Several studies have shown the anti-adhesive and antimicrobial effect of fucosylated oligosaccharides. Indeed, fucosylated oligosaccharides inhibit the adhesion of Campylobacter jejuni to the H(O) blood group epitope and reduce the risk of infection. rnrn2-FL also acts as an antifungal modulator and inhibits the adhesion of Candida albicans to human oral epithelial cells. rnrnRecent studies have shown that consumption of higher concentrations of alpha-1-2 fucosylated oligosaccharides resulted in lower mortality among infants who were HIV-infected or HIV-exposed but uninfected.rnrn
Immunomodulatory
Human milk oligosaccharides modify the infant's gut microbial environment. In vitro studies show that they directly modulate immune responses. A study of more than 400 infants shows that formulas containing 2-fucosyllactose increase the ratio of activated CD8+ T cells, reduce inflammatory cytokine production, and enhance immune development in infants.rnrn
Usages associés
Neurological
Research in rats has shown that oral supplementation with 2'-FL promotes brain development in both young and adult rats. In the 1990s, it was discovered that 2'-FL enhances long-term potentiation in the hippocampus, a phenomenon characterized by a strengthening of synaptic efficacy following high-frequency stimulation. However, further studies are required to confirm the role of 2'-FL in improving cognitive abilities in breastfed infants.rnrn
Usages associés
Safe dosage
Infant: 1.2 g/L
The U.S. Food and Drug Administration has recognized 2'-Fucosyllactose (2'-FL) as safe. In the European Union, 2'-FL is classified as a novel food. The European Food Safety Authority (EFSA) evaluated 2'-FL on June 29, 2015, and concluded that 2'-FL is safe for infants (up to one year of age) when added to infant formula, in combination with Lacto-N-neotetraose (LNnT), at concentrations of up to 1.2 g/L of 2'-FL and up to 0.6 g/L of LNnT, at a 2:1 ratio in reconstituted formulas. 2'-FL is also safe for young children (older than one year) when used in young-child formula, up to 1.2 g/L of 2'-FL, alone or in combination with LNnT up to 0.6 g/L, also in a 2:1 ratio.
Adult: 0.75 g - 2.9 g
It can be used safely, without exceeding the recommended daily dose.
Pregnant woman: 0.75 g - 2.9 g
It can be used safely, without exceeding the recommended daily dose. rnrn
Breastfeeding woman: 0.75 g - 2.9 g
It can be used safely, without exceeding the recommended daily dose. rnrn
Child: 1.2 g/L
The U.S. Food and Drug Administration has classified 2'-FL as safe. In the European Union, 2'-FL is considered a novel food. The European Food Safety Authority (EFSA) evaluated 2'-FL on June 29, 2015, based on scientific and technical information and reported that: "2'-FL is safe for infants (up to one year) when added to infant formula, in combination with LNnT, at concentrations up to 1.2 g/L of 2'-FL and up to 0.6 g/L of LNnT, in a 2:1 ratio in reconstituted formula. 2'-FL is safe for young children (older than one year) when added to follow-on formulas at concentrations up to 1.2 g/L of 2'-FL (alone or together with LNnT at concentrations up to 0.6 g/L, in a 2:1 ratio)." rnrn
