White mulberry: benefits, dosage, contraindications
Scientific name(s)
Morus alba, Morus indica
Family or group:
Plants
Active ingredients:
1-deoxynojirimycin
Indications
Scoring methodology
EFSA approval.
Type 2 diabetes ✪✪✪✪✪
White mulberry shows variable efficacy for type 2 diabetes. A meta-analysis of 4 clinical studies (12 weeks) concluded a modest improvement in glucose tolerance without an impact on HbA1c, the glycated hemoglobin biological marker of long-term glycemic control. The doses studied range from 500 mg to 4.6 g per day, containing 5-18 mg of deoxynojirimycin.
Posologie
Mulberry leaf extract improves glycemic response and insulinemic response to sucrose in healthy subjects: results of a randomized, double-blind, placebo-controlled study
Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis
Metabolic syndrome ✪✪✪✪✪
White mulberry appears to have promising effects on certain aspects of metabolic syndrome, although the evidence is limited. A clinical study shows that supplementation with white mulberry extract (300 mg twice daily for 12 weeks) modestly improves lipid profiles, with a decrease in total cholesterol and LDL. In obese patients with prediabetes, a dose of 4.6 g three times daily for 12 weeks slightly reduces fasting blood glucose and HbA1c. Finally, in overweight adults following a hypocaloric diet, a white mulberry extract (800 mg three times daily for 90 days) leads to a significant weight loss of 10%.
Posologie
Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
White mulberry supplementation as adjuvant treatment of obesity
Properties
Hypoglycemic




The white mulberry is recognized for its hypoglycemic properties, attributed mainly to the presence of bioactive compounds such as 1-deoxynojirimycin, a potent alpha-glucosidase inhibitor. This enzyme, involved in carbohydrate digestion, plays a key role in the release of glucose after a meal. By blocking its action, 1-deoxynojirimycin slows glucose absorption, reducing postprandial glycemic spikes.nnClinical studies support this effect. In addition, the antioxidant and anti-inflammatory compounds present in mulberry, such as flavonoids and anthocyanins, help reduce oxidative stress and the chronic inflammation associated with diabetes. This may also play a protective role against cardiovascular and neural complications related to the disease.nn
Usages associés
Metabolic




Studies in mice fed a high-fat diet show that adding white mulberry fruit powder or polysaccharides extracted from the leaves significantly improves glucose tolerance. These compounds reduce body fat accumulation and weight gain while lowering LDL cholesterol levels in the blood. This dual effect on carbohydrate and lipid metabolism suggests an important role in preventing metabolic syndrome. White mulberry may help with weight management. Deoxynojirimycin inhibits alpha-glucosidase enzymes in the intestine, thereby delaying the absorption of polysaccharides and limiting postprandial glycemic spikes. In addition, leaf polysaccharides inhibit pancreatic lipase, the key enzyme in the absorption of dietary fats. This dual action slows the absorption of energy macronutrients and supports weight control.
Usages associés
Safe dosage
Adult: 500 mg - 3000 mg
White mulberry leaf powder or extract: generally administered at 0.5 to 1 g three times a day, for a maximum duration of 3 months. Standardized products: Leaf powder standardized to 1.5% 1-deoxynojirimycin.
Precautions
Pregnant women: avoid
Insufficient data to ensure safety; avoid use except under medical supervision.
Lactating woman: avoid
Insufficient data to ensure safety; avoid use except under medical supervision.
Oral: leaf
500 mg
4 weeks
standardized extract
