Taxifolin: benefits, dosage, contraindications
Scientific name(s)
dihydroquercetin
Family or group:
Phytosubstances
Indications
Scoring methodology
EFSA approval.
Cognitive performance ✪✪✪✪✪
A recent clinical study examined the effects of a taxifolin-enriched food on brain activity and mental fatigue in healthy young adults. After a single dose of 108 mg of taxifolin, participants showed a significant improvement in mental calculation abilities and a reduction in mental fatigue, measured by cognitive tests (series of subtractions, visual vigilance tests) and visual analog scales.
Posologie
Oral administration
100 mg
standardized extract
Cardiovascular diseases ✪✪✪✪✪
Taxifolin has demonstrated antihypertensive properties by inhibiting the activity of the angiotensin-converting enzyme (ACE). It reduces peripheral resistance and stabilizes systolic and diastolic blood pressure. By inhibiting lipid peroxidation and reducing oxidized LDL levels, taxifolin also protects vascular walls from atherosclerotic damage. It also lowers serum and hepatic cholesterol levels and helps prevent cardiovascular complications.
Posologie
Oral administration
40 - 100 mg
standardized extract
Varicosities ✪✪✪✪✪
Taxifolin works by strengthening capillaries and improving blood microcirculation. These effects have been confirmed by clinical studies in Russia, where a supplementation of 40 mg/day significantly improved microcirculation in patients with vascular disorders.
Posologie
Oral administration
40 mg
standardized extract
Properties
Vascular effect
Taxifolin acts on the cardiovascular system by inhibiting oxidative stress and improving endothelial function. It reduces the activity of the angiotensin-converting enzyme (ACE), promotes the production of NO (nitric oxide) and protects vascular walls from damage. Studies in animal models show a decrease in hypertension and an improvement in lipid parameters, positioning taxifolin as a promising agent for the prevention of cardiovascular diseases.
Usages associés
Anticancer
Taxifolin inhibits the proliferation of cancer cells by inducing apoptosis and regulating signaling pathways such as AKT and NF-κB. It also prevents the formation of new tumor blood vessels (antiangiogenesis) and modulates reactive oxygen species (ROS), reducing inflammation associated with cancers.
Anti-inflammatory
Taxifolin reduces inflammation by modulating the NF-κB pathway and inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6. It also blocks the expression of cyclooxygenase-2 (COX-2), limiting the production of inflammatory mediators. These effects have been demonstrated in acute inflammation models, where taxifolin reduced edema and inflammatory markers.
Microcirculatory effect
Taxifolin acts by increasing cerebral blood flow, promoting better oxygenation and an energy supply to nerve cells.
Usages associés
Safe dosage
Adult: 40 mg - 100 mg (standardized extract)
There is no standardized dose for taxifolin, but available studies have mainly used doses around 100 mg per day, sometimes adjusted according to specific needs or therapeutic goals.
