SOD: benefits, dosage, contraindications
Other name(s)
Superoxide Dismutase
Scientific name(s)
Superoxide Dismutase
Family or group:
Enzymes
Indications
Scoring methodology
EFSA approval.
UV exposure ✪✪✪✪✪
SOD protects against premature skin aging related to the photo-oxidative reactions induced by UV. Indeed, these photo-oxidative reactions activate matrix metalloproteinases that degrade proteins of the extracellular matrix, particularly collagen.
Posologie
Oral
500 - 500 mg
2 - months
Adults
melon extract
Fatigue ✪✪✪✪✪
An extract of pistil pollen rich in SOD reduces lactic acid production in muscles and decreases muscle fatigue during exercise.
Posologie
Oral
136 - 272 mg
Adults
pistil pollen extract
Stress ✪✪✪✪✪
Clinical research shows that taking a specific melon extract providing 140 IU of superoxide dismutase daily for 84 days slightly reduces stress in healthy subjects.
Posologie
Orally
140 IU
melon extract
Oxidative stress ✪✪✪✪✪
Superoxide dismutase is an essential enzyme present in all living cells. Certain cellular processes produce reactive oxygen species, such as superoxide radicals, that can impair cellular function. Superoxide dismutase catalyzes the conversion of superoxide into oxygen and hydrogen peroxide, thereby reducing the damage caused by reactive oxygen species.
Posologie
Orally
10 - 20 mg
Healthy aging ✪✪✪✪✪
Superoxide dismutase (SOD) is considered an anti-aging enzyme. Oxygen free radicals generated in metabolic pathways lead to age-related deterioration through oxidative damage to biomolecules, with mitochondria being the primary target of attack. The accumulation of oxidative damage is considered one of the main mechanisms of aging. It has been suggested that new SOD mimetics could be useful to mitigate age-induced cognitive deficits and other aspects of physiological decline with aging.
Posologie
Orally
10 - 20 mg
Properties
Antioxidant
Superoxide dismutase is an essential enzyme present in all living cells. Certain cellular processes produce reactive oxygen species, such as superoxide radicals, which can impair cellular function. Superoxide dismutase catalyzes the conversion of superoxide into oxygen and hydrogen peroxide, thereby reducing damage caused by reactive oxygen species.
Usages associés
Anti-inflammatory
SOD can act as an inhibitor of neutrophil-mediated inflammation and could represent a novel therapeutic approach for ROS-dependent tissue injuries induced by neutrophils through several mechanisms. Preclinical studies have yielded encouraging results for its use as a human therapeutic agent in acute and chronic inflammatory conditions. Mn-SOD, extracellular Mn-SOD, and Cu,Zn-SOD have been described as potential inhibitors of inflammation.
Anti-aging
SOD is considered an anti-aging enzyme. Oxygen free radicals generated in metabolic pathways lead to age-related deterioration through oxidative damage to biomolecules, with mitochondria being the primary target of attack. The accumulation of oxidative damage is considered one of the main mechanisms of aging. It has been suggested that novel SOD mimetics could be useful to mitigate age-related cognitive impairments and other aspects of physiological decline with aging.
Usages associés
Immune stimulant
Superoxide dismutase strengthens the body's natural defenses against excess free radicals and helps maintain the immune system.
Safe dosage
Adult: 500 mg - 500 mg (melon extract)
SOD is safe when used orally in an appropriate manner. A dose of 500 mg of melon extract, equivalent to 500 IU of SOD, is used for 1 to 2 months.
Precautions
Pregnant women: avoid
Avoid use in pregnant women due to lack of reliable and sufficient information.
Breastfeeding women: avoid
Avoid use in breastfeeding women due to lack of reliable and sufficient information.
