Rutin: benefits, dosage, contraindications
Family or group:
Phytochemicals
Indications
Scoring methodology
EFSA approval.
Venous insufficiency, Heavy legs ✪✪✪✪✪
According to a recent Cochrane review, rutin, classified as a phlebotonic, has primarily been studied for its effects in the treatment of chronic venous insufficiency (CVI). It acts by slightly reducing edema of the lower limbs (an effect measured by ankle circumference and leg volume), while improving symptoms such as pain, heaviness, and itching. Studies report moderate effectiveness, with a reduction in ankle circumference of about 4.27 mm compared with placebo, as well as a subjective improvement in sensations of heaviness and pain. However, the quality of the data is considered moderate to low due to variability in methodologies and potential biases. The benefits of rutin appear modest and further studies are needed to confirm its effectiveness in managing CVI symptoms.
Posologie
Oral administration
500 mg
dry extract
Synergies
Wrinkles ✪✪✪✪✪
A randomized, double-blind clinical study evaluated the anti-aging effects of a cream containing 2% rutin. Over 4 weeks, 40 women aged 30 to 50 applied 2 g of cream (2% rutin), morning and evening, to their face. Measurements included skin elasticity, dermal density, and wrinkles. The study showed significant improvements: - Skin elasticity: increase of 25.34% after 2 weeks and 40.50% after 4 weeks. - Dermal density: increase of 10.73% after 2 weeks and 20.16% after 4 weeks. - Wrinkles (crow's feet): reduction in length (23.90%) and area (27.19%) after 4 weeks. - Under-eye wrinkles: reduction in number by 31.96% after 2 weeks and by 49.48% after 4 weeks. Rutin acts by increasing the expression of genes related to collagen production and by inhibiting enzymes that degrade the extracellular matrix (MMP1). It also reduces oxidative stress induced by free radicals, a key factor in skin aging.
Posologie
Topically
2%
cream
Synergies
Properties
Venotonic
Rutin is particularly known for its beneficial effects on vascular health. By strengthening capillary walls, it reduces their permeability and fragility, and helps prevent edema and improve blood circulation. Studies show that rutin improves endothelial function by increasing the production of nitric oxide, a natural vasodilator, in human endothelial cells. This helps regulate blood pressure and reduces vascular inflammation, making it relevant in the treatment of chronic venous disorders such as varicose veins and venous insufficiency.
Usages associés
Antioxidant
Rutin is a powerful antioxidant capable of scavenging free radicals and reducing oxidative stress. By acting as a metal chelator and neutralizing reactive oxygen species, it protects cells from damage induced by oxidative stress, a key factor in the development of chronic diseases such as cardiovascular diseases, neurodegenerative disorders, and certain cancers. In addition, it stimulates antioxidant enzymes such as glutathione peroxidase (GPX) and superoxide dismutase (SOD). These properties have also been associated with a reduction in skin damage caused by ultraviolet rays.
Usages associés
Safe dosage
Adult: 600 mg
Up to 600 mg per day for a maximum duration of 12 weeks has been used with apparent safety in clinical studies. Topical use: Creams containing rutin, typically at concentrations of 2%, have been used without reported adverse effects.
