Raspberry: benefits, dosage, contraindications

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The raspberry is a shrub 1 to 2 m tall; its blue-green stems are equipped with fine reddish prickles, its leaves are a pronounced green on the upper side and white and downy underneath. Its white flowers open from May to July, then give rise to velvety red fruits, sweet and fragrant: these are raspberries. The raspberry is native to Europe and temperate Asia; it is cultivated but can be found growing wild in woods and at altitudes up to 2000 m. The parts used therapeutically are the fruits and the leaves. The raspberry contains anthocyanidins (responsible for the red color), ellagitannins, flavonols such as quercetin and kaempferol, catechins and phenolic acids. Among other notable active compounds are ascorbic acid (vitamin C), beta-carotene, glutathione, vitamin E, as well as ketones, which are popular for their supposed effect on weight loss. Raspberry leaves are also rich in flavonols such as quercetin and kaempferol, and in ellagic acid. Traditionally, the leaf of the raspberry is used for gastrointestinal disorders including diarrhea and inflammations of the mouth and throat. The raspberry is also known as the undisputed woman's remedy. The leaves are used as an antispasmodic in menstrual disorders, and are said to facilitate childbirth

Scientific name(s)

Rubus idaeus

Family or group: 

Plants

Active ingredients:

Ellagic acid

Anthocyanins


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Wrinkles
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Clinical research conducted on women aged 30 to 65 shows that applying a solution containing a raspberry leaf cell culture extract, 20% vitamin C and 1% vitamin E to the face every night for 8 weeks improves skin tone, elasticity, radiance, smoothness, and the appearance of wrinkles.

Posologie

posologieTopical: leaf

formulationlotion, liquid extract


Dysmenorrhea
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The EMA indicates that raspberry leaves are used for the symptomatic relief of minor spasms associated with menstruation. In gemmotherapy, raspberry buds are very specific for painful menstruation due to their muscle-relaxing action.

Posologie

posologieOral use: buds, leaf

posologie300 - 900 mg

formulationinfusion, gemmotherapy, dry extract


Menopause
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The raspberry buds, due to their estrogenic action, stimulate the ovaries and can help reduce hot flashes.

Posologie

posologieBy mouth: buds

formulationgemmotherapy


Synergies


Pregnancy
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Raspberry leaf tea is used during pregnancy, particularly to facilitate labor. Clinical research shows that daily intake of 2.4 g of raspberry leaf, from the 32nd week of gestation until delivery, does not reduce the need for analgesics during the perinatal period compared with placebo.

Posologie

posologieOral use: leaf

posologie1.4 g

formulationinfusion, dry extract


Properties


Estrogenic action

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Raspberry leaf may have estrogenic effects. In an animal model, raspberry leaf appears to increase serum ceruloplasmin oxidase activity, which is a measure of estrogenic activity in the liver.

Usages associés

Menopause

Antioxidant

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Raspberry fruits and leaves appear to have antioxidant effects according to laboratory research. Known antioxidant constituents include anthocyanins, ellagic acid, and other polyphenols.

Usages associés

Wrinkles

Antispasmodic

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The effects of raspberry leaf on smooth muscles, such as those of the uterus, appear to be variable. Different components of raspberry leaf seem to stimulate or contract uterine smooth muscle. Clinically, red raspberry leaf may have stimulant or spasmolytic effects. It has been observed that these effects may depend on dose and tissue. For example, at low doses, raspberry leaf may cause greater contraction, while at higher doses it may have spasmolytic effects and reduce contraction. Similarly, it may decrease contraction of tonic tissues and increase contraction of relaxed tissues.

Usages associés

Dysmenorrhea, Pregnancy

Anti-inflammatory

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Raspberry extracts inhibit the enzymes cyclooxygenase-2 (COX-2) and lipoxygenase in vitro, which suggests they may have anti-inflammatory activity. Another study showed that raspberry supplementation activates AMP-activated protein kinase (AMPK) α1, leading to a reduction in lipid accumulation in skeletal muscle and a decreased inflammatory response. This suggests that raspberries may play a role in reducing obesity-related inflammation and improving insulin sensitivity.

Usages associés

ENT infections, Diarrhea

Antibacterial

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Laboratory research suggests that raspberry and some of its components may have antibacterial effects. Its components have been shown to inhibit the growth of various pathogenic intestinal bacteria, such as Campylobacter, Salmonella, Shigella, and Escherichia coli, probably by disrupting the outer membrane of the bacteria.

Usages associés

ENT infections, diarrhea


Safe dosage

Adults 18 years and older: 339 mg - 900 mg (dry extract)

Dry extract: 113-226 mg, up to 3 to 4 times a day to be taken after meals. Decoction: Crushed plant material for the preparation of infusions for oral-mucosal use: 1.5 to 8 g of crushed plant material in 150 ml of boiling water, 3 times a day, to be used as a gargle.


Interactions

Médicaments

Antiplatelet agents/Anticoagulants: low interaction

In vitro research suggests that raspberry leaf extract has antiplatelet activity and could enhance the effects of antiplatelet medications. For example, anticoagulant agents include heparin and warfarin.

Insulin: minor interaction

Raspberry leaf could lower glucose levels in patients treated with insulin. In a case report (Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitu) a 38-year-old woman with gestational diabetes, whose blood glucose was controlled by medical nutritional therapy and insulin, developed hypoglycemia after consuming two servings of raspberry leaf tea per day for 3 days starting at 32 weeks' gestation. The patient had to reduce her insulin doses.


Precautions

Pregnant women: use with caution

Raspberry leaf is used by midwives to facilitate childbirth. There is evidence that raspberry leaf, at doses up to 2.4 g per day, from the 32nd week of pregnancy until delivery, can be used safely.

Breastfeeding women: avoid

Safety during breastfeeding has not been established. In the absence of sufficient data, use during breastfeeding is not recommended.