Polyporus: benefits, dosage, contraindications

Mis à jour le 7 November 2025

Polyporus umbellatus, also called "umbrella polypore", is a rare medicinal mushroom that grows mainly in the temperate regions of Asia and Europe. Used for centuries in traditional Chinese medicine, it is prized for its unique therapeutic properties, particularly in supporting kidney and immune health. Polyporus umbellatus is primarily recognized for its diuretic, detoxifying, and immunomodulatory effects. Its richness in polysaccharides and beta-glucans helps stimulate the immune system while protecting cells from oxidative damage. It also exhibits antiproliferative activity and helps reduce edema related to cancer treatments. A recent study highlighted the benefits of Polyporus umbellatus in managing edema associated with oncological treatments. Daily administration of 400 mg of Polyporus umbellatus extract resulted in a significant improvement in water retention and a reduction in side effects related to conventional treatments, such as chemotherapy.

Scientific name(s)

Polyporus umbellatus

Family or group:

Mushrooms

Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.

One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.

Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.

No clinical studies to date that can demonstrate the indication.

Edema
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Traditionally, Polyporus umbellatus is used in Chinese medicine to treat edema. Ancient writings, such as the Shen Nong's Herbal Classic, describe its effectiveness in reducing water retention by stimulating the elimination of bodily fluids, without major side effects. Formulas like Wulingsan often include this mushroom to support kidney function.

Posologie

Oral administration

5 - 20 mg/kg

Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: a review

Cancer
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Polysaccharides extracted from Polyporus umbellatus (PUPs) have shown inhibitory effects on tumor cell growth, notably sarcoma 180. Their anticancer activity is attributed to their ability to stimulate immune responses and to induce apoptosis in cancer cells. Some isolated compounds, such as polyporusterones (A, B, C) and ergone, have demonstrated cytotoxic activities against human tumor cell lines, notably liver cancer (Hep3B) and colon cancer (HT-29). In animal models, extracts of Polyporus umbellatus significantly reduced tumor size and prolonged survival. These results indicate a promising potential for Polyporus umbellatus as an adjunctive agent in cancer treatment,

Posologie

Oral

5 - 20 mg/kg

Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: a review

Properties

Anticancer

Polyporus umbellatus contains bioactive polysaccharides (PUPs) that are notable for their antitumor activity. These polysaccharides act by inhibiting tumor cell proliferation and stimulating the immune system. In vivo studies have shown that doses of 200 to 400 mg/kg significantly reduce tumor size and prolong survival in mice with hepatomas. These effects are attributed to the modulation of pro-apoptotic and anti-inflammatory signaling pathways.

Usages associés

Cancer

Polysaccharides from Polyporus umbellatus: A review on their extraction, modification, structure, and bioactivities

Diuretic

Traditionally used in Chinese medicine for its diuretic properties, Polyporus umbellatus promotes the elimination of excess bodily fluids and the reduction of edema. A recent clinical study confirmed this effect, showing that a dose of 400 mg/day improves renal function and reduces edema markers without notable side effects. This effect is particularly beneficial for patients with mild renal insufficiency or edema related to oncological treatments.

Usages associés

Edema

Polysaccharides from Polyporus umbellatus: A review on their extraction, modification, structure, and bioactivities

Safe dosage

Adult: 400 mg (standardized extract)

Available formulations generally recommend 400 mg to 1 g/day of concentrated extract, to be taken in one or two doses.

Precautions

Pregnant women: avoid

The use of Polyporus umbellatus in pregnant women is not recommended in the absence of specific clinical safety data.

Breastfeeding women: avoid

The use of Polyporus umbellatus in breastfeeding women is not recommended in the absence of specific clinical safety data.

Conseil scientifique