Melilot: benefits, dosage, contraindications

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Melilot is a biennial plant of the Fabaceae family, common in Europe. It grows on calcareous or slightly saline soils and adapts to altitudes up to 2200 meters. Its stems can reach one meter in height and bear trifoliate leaves and fragrant yellow flowers gathered in clusters, blooming from May to September and much prized by bees, hence the name "meli" meaning "honey". Historically, melilot was already mentioned by figures of ancient medicine such as Hippocrates and Dioscorides for its effects on stomach and liver pain. In the Middle Ages, its sedative properties were recognized. The flowering tops of the plant are the parts used in herbal medicine. Melilot is rich in coumarins, notably melilotin which gives it mild anticoagulant properties. It also contains flavonoids such as kaempferol and phenolic acids such as salicylic acid. These components contribute to its veno-lymphatic effects, reducing inflammation and improving microcirculation. Modern uses of melilot extend to treatments for venous insufficiency, lymphedema and hemorrhoids. Its extracts are standardized to contain at least 0.3% coumarin, thereby ensuring efficacy and safety in its therapeutic applications.

Scientific name(s)

Melilotus officinalis

Family or group: 

Plants

Active ingredients:

Coumarins

Phenolic acids


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Contusion, Bruising
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Melilot has traditionally been used to treat bruises and hematomas because of its beneficial effects on circulation and its anti-inflammatory action. Active compounds such as coumarin in melilot reduce capillary permeability and improve microcirculation, which can help reduce swelling and accelerate the resolution of bruises. The EMA also approves melilot for the treatment of minor skin inflammations, confirming its traditional use in these contexts.

Posologie

posologieTopical use: flowering tops

posologie3 - 6 g

formulationpatch, fluid extract


Hemorrhoids
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Melilot, thanks to its anti-inflammatory and vasoprotective properties, has traditionally been used to relieve hemorrhoid symptoms.

Posologie

posologieOral use: flowering tops

posologie480 - 750 mg

formulationhydroalcoholic extract, dry extract


Venous insufficiency, Varicose veins, Varicosities, Oedema
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Melilot offers benefits thanks to its effects on the venous-lymphatic system. By improving vascular tone and increasing lymphatic flow, melilot helps reduce venous stasis, a key factor in the development of varicose veins and hemorrhoids. In addition, activation of phagocytes by melilot contributes to reducing local inflammation, thereby providing relief in cases of varicose veins and hemorrhoids, where inflammation and pain are often present. Melilot's ability to promote healing and tissue regeneration may also be beneficial in repairing vascular damage associated with phlebitis. The European Medicines Agency (EMA) recognizes melilot as a traditional product to relieve symptoms of discomfort and heaviness in the legs associated with minor venous circulatory disorders.

Posologie

posologieOral route: flowering tops

posologie480 - 750 mg

formulationhydroalcoholic extract, dry extract


Heavy legs
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Melilot is traditionally used to relieve symptoms of heaviness in the legs associated with mild venous circulatory disorders, in accordance with the EMA's indication.

Posologie

posologieTopical route: flowering tops

posologie3 - 6 g

formulationpatch, fluid extract


Properties


Vascular effect

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Melilot has notable effects on the vascular system, particularly due to its myotropic properties that actively stimulate the lymphatic and venous systems. The coumarins, active compounds in melilot, improve vessel tone by increasing the rate and force of lymphatic contractions while reducing capillary permeability. This action promotes better tissue oxygenation through a significant improvement in microcirculation. These combined effects contribute to improved management of lymphedemas and to an overall increase in lymphatic vascular activity.

Usages associés

Contusion

Microcirculatory effect

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Melilot contains substances called benzopyrones, particularly alpha-benzopyrones such as coumarins. These compounds improve blood circulation in small vessels by stimulating contraction of lymphatic vessels and by activating macrophages to produce a protein-degrading effect. This can help reduce swelling and inflammation in the affected tissues.

Usages associés

Venous insufficiency, Hemorrhoids, Heavy legs

Antiplatelet agents/Anticoagulant

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Coumarins have anticoagulant activity.


Safe dosage

Adults aged 18 and over:

- For internal use, the recommended dose is 1 to 5 mg of coumarin per day, administered as a melilot preparation. - As an infusion, the recommended dose is 1 to 1.2 g per infusion, 1 to 2 times per day. - As a dry extract, the recommended dose is 250 mg, 3 times per day.


Interactions

Médicaments

Antiplatelet agents/Anticoagulants: moderate interaction

Melilot contains coumarinic acids, which have anticoagulant activity.


Contraindications

Liver disorders: contraindicated

Melilot is contraindicated in people with liver problems.

Children under 18 years: contraindicated

Melilot is contraindicated in pregnant and breastfeeding women, as well as in children under 18 years of age.

Pregnant women: contraindicated

Melilot is contraindicated in pregnant and breastfeeding women, as well as in children under 18 years of age.

Breastfeeding women: contraindicated

Melilot is contraindicated in pregnant and breastfeeding women, as well as in children under 18 years of age.