Manganese: benefits, dosage, contraindications
Other name(s)
Mn
Scientific name(s)
manganese
Family or group:
Minerals and trace elements
Indications
Scoring methodology
EFSA approval.
Manganese deficiency ✪✪✪✪✪
Manganese deficiency is rare; it manifests as slowed growth, damage to the skin and appendages (dermatitis, hair pigmentation disorders), a decrease in blood cholesterol, and even impaired reproductive functions. Recommended intakes are 2 to 5 mg per day. The former Afssa (French Food Safety Agency, now Anses) set a safety limit of 10 mg per day, which should never be exceeded.
Posologie
Oral
2 - 10 mg
Premenstrual syndrome ✪✪✪✪✪
Clinical research shows that taking 1.0 mg or 5.6 mg of manganese per day in combination with 587 mg or 1336 mg of calcium per day for about 24 weeks improves premenstrual syndrome symptoms, notably pain, anxiety, irritability, and mood disturbances. However, it is not known whether this benefit is due to the calcium, the manganese, or the combination of the two.
Posologie
Oral
1 - 5.6 mg
24 - weeks
Synergies
Osteoarthritis ✪✪✪✪✪
The intake of a specific product containing 228 to 304 mg of manganese ascorbate (approximately 31-41 mg of elemental manganese), glucosamine hydrochloride (1500 to 2000 mg) and chondroitin sulfate (1200 to 1600 mg) taken orally once daily for 4 months improves pain and quality of life in patients with knee and lumbar spine osteoarthritis.
Posologie
Orally
228 - 304 mg
4 - months
manganese ascorbate
Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis.
Osteoporosis ✪✪✪✪✪
The oral intake of 5 mg per day of manganese in combination with 1000 mg of elemental calcium, 15 mg of zinc and 2.5 mg of copper for 2 years helps reduce spinal bone loss in postmenopausal women. On the other hand, the oral intake of a specific product containing 1.8 mg of manganese, 600 mg of calcium, 200 IU of vitamin D (cholecalciferol), 40 mg of magnesium, 7.5 mg of zinc, 1 mg of copper and 250 mcg of boron, taken twice daily for one year, improves bone density in women with osteopenia.
Posologie
Orally
1.8 - 5 mg
2 - years
Properties
Essential
Manganese is an essential nutrient that acts as a cofactor in several metabolic and enzymatic reactions. Manganese is involved in the metabolism of amino acids, cholesterol and carbohydrates, normal cell growth, the generation of the immune response, bone formation and the regulation of glucose. Manganese is a component of an antioxidant enzyme known as superoxide dismutase (SOD), and specifically a variant known as manganese superoxide dismutase (MnSOD). Other enzymes of which manganese is a known component include pyruvate carboxylase and glutamine synthetase located in the cytoplasm of glial cells, where it converts glutamate (a neurotransmitter) into glutamine. The European health authorities (EFSA, European Food Safety Authority and the European Commission) have determined that products containing manganese may claim to contribute to: to normal energy metabolism, to the maintenance of normal bones, to the maintenance of normal formation of connective tissue and to the protection of cells from free radicals (antioxidant effect), if and only if these products contain at least 0.3 mg of manganese per 100 g, 100 ml or per package if the product contains only one serving.
Usages associés
Antioxidant
Manganese has a primary role in the body as a component of an antioxidant enzyme known as superoxide dismutase (SOD), but specifically a variant known as manganese superoxide dismutase (MnSOD).
Bone density
Researchers believe that manganese may play a role in osteoporosis. Indeed, a decrease in plasma manganese concentrations has been reported in women with osteoporosis. Furthermore, bone mineral density improved when trace elements, including manganese, were included with calcium in their diet or supplements.
Usages associés
Safe dosage
Adults aged 18 years and older: 3 mg
Infants aged 7 to 11 months: 0.5 mg
Children aged 1 to 3 years: 0.5 mg
Child aged 4 to 6 years: 1 mg
Child aged 7 to 10 years: 1.5 mg
Child aged 11 to 14 years: 2 mg
Child aged 15 to 17 years: 3 mg
Interactions
Médicaments
Antipsychotics: moderate interaction
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. It is thought that the combination of manganese with haloperidol, phenothiazines, or other antipsychotic medications may increase the risk of manganese toxicity in some patients.
Quinolones: moderate interaction
Theoretically, manganese could reduce the absorption of quinolones, which include ciprofloxacin (Cipro), levofloxacin (Levaquin), gatifloxacin (Tequin), sparfloxacin (Zagam)...
Tetracyclines: moderate interaction
Theoretically, manganese could reduce the absorption of tetracyclines.
Plantes ou autres actifs
Manganese: minor interaction
Concurrent administration of calcium and manganese may decrease manganese absorption.
Manganese: minor interaction
Co-administration of iron and manganese decreases manganese absorption.
Manganese: minor interaction
Co-administration of zinc and manganese increases manganese absorption.
Precautions
Pregnant women aged 18 years and older: use with caution
Breastfeeding women aged 18 years and older: use with caution
Liver disorders: use with caution
Chronic liver disease may lead to manganese accumulation and toxicity.
