L-cysteine: benefits, dosage, contraindications

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L-cysteine is a semi-essential amino acid used in protein synthesis. Although the body can produce it from the amino acid methionine, L-cysteine plays several key roles that support overall health. Its side chain contains sulfur, which is crucial for the formation of disulfide bonds that help stabilize protein structures. It is important not to confuse L-cysteine with N-acetylcysteine (NAC); although the two are related, their uses and benefits are slightly different. Beyond its contribution to protein structure, L-cysteine is involved in the synthesis of several vital compounds, including glutathione, a powerful antioxidant that protects cells from damage caused by free radicals and toxins. It also contributes to the production of taurine, sulfate, and coenzyme A, which are essential for proper metabolic function and cardiovascular health. Found naturally in certain foods such as soy, meats, or nuts, the dietary requirement for L-cysteine is usually low because it is synthesized endogenously. However, it is often used as a supplement for its antioxidant effects and to support glutathione production, particularly in situations where the body is exposed to increased oxidative stress, such as during chronic illness or recovery after intense physical exertion. Although L-cysteine is being explored for its potential therapeutic effects in various conditions such as addictions or the cosmetic appearance of hair and nails, it is important to note that scientific evidence regarding its effectiveness in these areas remains limited.

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Amino acids


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Hair care, Skin healing
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L-cysteine is consumed for its benefits for the beauty of the skin and hair. nnIn cosmetics, L-cysteine is incorporated into supplements for its ability to promote scalp health and hair vigor, as it is essential for the synthesis of keratin, a protein that strengthens hair. nnL-cysteine helps reduce hair loss and improve hair texture. For the skin, it supports collagen production, improving skin elasticity and texture. Its antioxidant properties combat free radical damage, thereby promoting healthy skin. nn

Posologie

posologieOrally

posologie500 mg


Smoking cessation
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Preliminary clinical studies have shown that the use of a slow-release tablet containing 3 mg of L-cysteine with each cigarette for 6 months does not increase the chances of quitting smoking compared with a placebo. nnA more qualitative study conducted by the same research group showed that the use of this tablet increases the chances of quitting smoking by about 51% compared with a placebo.nn

Posologie

posologieOrally

posologie3 mg


Skin health
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A randomized controlled trial evaluated the effect of supplementation with L-glutathione and L-cysteine on skin lightening in 124 women aged 30 to 50 years with at least one dark spot on the face. The results showed that the combination of L-cysteine and L-glutathione lightened the skin on the cheeks and the lower forearm. nnNo effect was observed with the placebo. nn

Posologie

posologieOral

posologie500 mg


Alcoholism
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A small clinical study showed that an immediate-release product containing L-cysteine (1200 mg) in combination with other ingredients modestly reduced hangover symptoms such as nausea, headache, stress, and anxiety when taken six times between 7:00 PM and midnight in conjunction with alcohol (1.5 g/kg over 3 hours), compared to placebo. nnHowever, other researchers questioned the validity of the statistical methods used in this study and suggest that not all reported findings were statistically significant.nn

Posologie

posologieOral

posologie1200 mg


Properties


Antioxidant

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L-cysteine, a precursor of glutathione, methionine and taurine, plays a key role because of its antioxidant effects. In humans, L-cysteine supplementation improved antioxidant status after athletic performance. In animal studies, L-cysteine modestly reduced levels of certain free radicals and oxidative markers in brain tissue and increased antioxidant activity. It also slightly increased the activities of the antioxidant enzymes catalase and glutathione reductase, although it had no effect on other markers of oxidation.


Neurological

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Acting as a neuromodulator, L-cysteine is essential for glutathione synthesis, playing a role in redox balance. In the laboratory, it antagonizes GABA-alpha receptors. Additionally, L-cysteine has been studied for alcohol use disorder. It was found to reduce the motivation to self-administer ethanol in animal models. However, neurotoxic effects have been observed, possibly due to the formation of L-cysteine metabolites.

Usages associés

Smoking cessation, Alcoholism


Safe dosage

Adults: 500 mg - 1200 mg

There is no typical dosage. Doses used in studies range from 500 mg to 1200 mg.nn