Glucomannan: benefits, dosage, contraindications
Family or group:
Phytochemicals
Indications
Scoring methodology
EFSA approval.
Constipation ✪✪✪✪✪
Glucomannan is generally effective in treating constipation in adults. Clinical research shows that an oral intake of 1 to 1.5 g of glucomannan three times a day for 3 to 5 weeks can relieve constipation. It acts as a bulk-forming laxative by increasing stool volume. In pregnant women, the combination of glucomannan and lactulose also appears to be effective in alleviating constipation.
Posologie
Oral administration
1 - 1.5 g
Fiber (glucomannan) is beneficial in the treatment of childhood constipation
Glucomannan is not effective for the treatment of functional constipation in children: a double-blind, placebo-controlled, randomized trial
Type 2 diabetes ✪✪✪✪✪
Limited evidence suggests that glucomannan may improve glycemic control and lipid profiles in patients with type 2 diabetes. The usual dose ranges from 3 to 15 g per day for 4 to 12 weeks, showing a modest improvement in fasting glucose, total cholesterol, and LDL, but with no significant impact on triglycerides.
Posologie
Oral
3 - 15 g
Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis
Nutraceutical resources for diabetes prevention--an update
Dyslipidemia ✪✪✪✪✪
The majority of clinical research indicates that glucomannan can lower cholesterol levels in healthy individuals as well as in those with hyperlipidemia. Meta-analyses show that taking 2.5 to 15 g of glucomannan per day for up to 12 weeks can significantly reduce total cholesterol, LDL, and triglycerides. Glucomannan is often taken at doses of 5 to 10 g per day in adults and 2 to 3 grams per day in children.
Posologie
Oral
5 - 10 g
Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis
A systematic review and meta-analysis of randomized controlled trials of the effect of konjac glucomannan, a viscous soluble fiber, on LDL cholesterol and the new lipid targets non-HDL cholesterol and apolipoprotein B
Obesity ✪✪✪✪✪
Although some low-quality research suggests that oral glucomannan may be beneficial for a slight improvement in body weight, other studies do not support this claim. Meta-analyses on the use of glucomannan to improve weight and body composition in overweight or obese adults and children show mixed results. One analysis suggests that glucomannan reduces body weight by about 0.8 kg compared with placebo, while another observes no improvement. The reasons for these divergent results may be related to differences in the populations studied, dosages and treatment duration, as well as the often poor methodological quality of studies conducted to date.
Posologie
Oral
2 - 4 g
Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
Gummies candy enriched with Konjac glucomannan reduces hunger intensity and waist circumference of overweight individuals
Properties
Cardiovascular
Glucomannan could improve glycemic control by slowing gastric emptying and increasing the viscosity of gastrointestinal contents, which has a positive impact on blood glucose levels. Furthermore, glucomannan promotes fecal excretion of cholesterol and bile acids and inhibits hepatic cholesterol synthesis. Clinical evidence also suggests that glucomannan may reduce triglycerides by increasing levels of lipoprotein lipase (LPL) and GPIHBP1 protein, which work together to hydrolyze triglycerides and deliver lipid nutrients to target tissues.
Usages associés
Laxative
Glucomannan, a water-soluble carbohydrate, acts as a laxative by increasing water absorption into the stool and reducing intestinal transit time. Clinical studies have shown its effectiveness in the treatment of constipation.
Safe dosage
Adult: 3 g - 10 g
Glucomannan is commonly used at doses of 3 to 10 grams per day, taken as a single dose or in divided doses, for a duration of up to 3 months. Warning: drink plenty of water. Cases of choking and esophageal or gastrointestinal obstruction have been reported when glucomannan products are taken dry.
Child: 2 g - 5 g
In children, glucomannan has been used at doses of 2 to 5 g per day, taken as a single dose or in divided doses, for periods of up to 4 months. Caution: drink plenty of water. Cases of choking and esophageal or gastrointestinal obstruction have been reported when glucomannan-containing products are taken dry.
Interactions
Médicaments
Oral medications: moderate interaction
Glucomannan may reduce the absorption of certain medications due to the viscosity and swelling effect of glucomannan. To avoid changes in absorption, it is recommended to take glucomannan 30 to 60 minutes after taking oral medications.
