Eucalyptus: benefits, dosage, contraindications

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Eucalyptus is a genus of flowering trees and shrubs in the family Myrtaceae. Eucalyptus species are native to Australia but now grow in many tropical and subtropical climates. Eucalyptus leaves can be steam-distilled to extract eucalyptus oil. The parts of eucalyptus used therapeutically are the leaf and the essential oil. The constituents of the leaf include the monocyclic sesquiterpenoid litseagermacrane, prenylated phloroglucinols, methylated flavones and triterpenes. Other constituents include the macrocarpals. The oil contains terpenes such as the 1,8-cineole (=Eucalyptol, at least 70%), the pinenes, phellandrene and limonene. Eucalyptus is used for many conditions: - Internal use Adjunctive treatment of chronic obstructive respiratory diseases, notably bronchitis and asthma, as well as symptomatic relief of colds and catarrhs of the upper respiratory tract. - External use Symptomatic treatment of colds and rheumatic conditions.

Scientific name(s)

Eucalyptus globulus, Eucalyptus radiata

Family or group: 

Plants

Active ingredients:

Eucalyptol


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Asthma
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Preliminary clinical research suggests that eucalyptol, a constituent of eucalyptus oil, has mucolytic properties. When taken orally, it may allow a reduction in the dosage of oral steroids in patients suffering from severe asthma.nnESCOP lists eucalyptus oil as an adjuvant treatment for chronic obstructive respiratory conditions, including bronchial asthma.nn

Posologie

posologieOral: leaf

posologie200 - 600 mg

formulationessential oil, dry extract


Bronchitis
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Some clinical research suggests that oral intake of a product marketed under the name GeloMyrtol®, containing essential oils of eucalyptus and myrtle leaves with sweet orange and lemon peels, at a dose of 900 - 1200 mg/day for at least 2 weeks improves symptoms and reduces exacerbations of chronic and acute bronchitis.nnESCOP lists eucalyptus oil as an adjuvant treatment for chronic obstructive respiratory conditions, including bronchitis.nn

Posologie

posologieOral: leaf

posologie900 - 1200 mg

duration2 - weeks

formulationessential oil, GeloMyrtol®


Synergies


Gingivitis
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Preliminary clinical research shows that chewing gum containing 0.4 to 0.6% eucalyptus extract, taken five times a day for four days, improves gingivitis.

Posologie

posologieOral (buccal): leaf

formulationessential oil


Dental plaque
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Preliminary clinical research shows that chewing gum containing 0.3 to 0.6% eucalyptus extract, taken 3 to 5 times per day for a period ranging from 4 days to 12 weeks, reduces dental plaque compared with placebo.

Posologie

posologieOral (buccal): leaf

formulationessential oil


Common cold
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The EMA indicates that eucalyptus oil is a traditional medicine used to relieve cough associated with the common cold.nnESCOP indicates it for the symptomatic relief of colds and catarrhs of the upper respiratory tract.nn

Posologie

posologieOral: leaf

posologie200 - 1000 mg

formulationessential oil, dry extract


Properties


Mucolytic

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Thanks to its high content of 1,8-cineole (eucalyptol), the essential oil is expectorant and mucolytic; it thins bronchial secretions to facilitate their expulsion. It also promotes relaxation of the airway smooth muscles.

Usages associés

Asthma, Bronchitis, Cold

Anti-inflammatory

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Eucalyptus essential oil (EO) contains 60 to 90% eucalyptol (1,8-cineole), and eucalyptol has been shown to have analgesic and anti-inflammatory effects. Preliminary research suggests that eucalyptol may block the production of arachidonic acid metabolites involved in pain. It may also inhibit cyclooxygenase pathways. Eucalyptol and other constituents also appear to inhibit the production of cytokines responsible for inflammation, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, leukotriene B4 and thromboxane B2. Besides the EO, ethanolic extracts of eucalyptus leaves also appear to have anti-inflammatory activity. This could explain its use in asthma.

Usages associés

Asthma, Bronchitis, Cold

Antiparasitic

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Eucalyptus oil is used in some topical solutions against head lice. The ovicidal effects of the terpenes present in the oil have been demonstrated in vitro.

Usages associés

Lice

Antimicrobial

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Eucalyptus leaf extracts and their isolated components appear to have antimicrobial and antifungal activity.

Usages associés

Gingivitis, Dental plaque

Analgesic

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The essential oil is traditionally recommended for symptomatic relief of localized muscle pain.

Usages associés

Rheumatism

Hypoglycemic

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An aqueous extract of eucalyptus leaves appears to have hypoglycemic activity. Preliminary research shows that it increases insulin secretion and improves glucose uptake and metabolism by muscles.


Safe dosage

Adults 12 years and older: 200 mg - 1000 mg

For oral use, single dose: 100-200 mg, 2 to 5 times per daynnFor topical use, a few drops on the chest or back, 2 to 3 times per day.nnSingle dose for semi-solid dosage forms (10% eucalyptus oil): apply a thin layer to the chest and back, 2 to 3 times per day.nn

Children aged 4 to 12 years:

For topical use only.nn


Interactions

Médicaments

Aminopyrine: moderate interaction

In human studies, inhalation of 1,8-cineole increased the plasma disappearance of aminopyrine.

Amphetamines: low interaction

Animal studies suggest that inhalation of eucalyptol may reduce amphetamine levels in the blood.

Antidiabetic drugs: low interaction

Animal research suggests that eucalyptus leaf may have hypoglycemic activity and could have additive effects when used with antidiabetic medications.

Pentobarbital: moderate interaction

Animal studies suggest that inhalation of eucalyptol reduces the level of pentobarbital reaching the brain.


Precautions

Type 2 diabetes: use with caution

Preliminary research suggests that eucalyptus leaves may have hypoglycemic activity and could theoretically have additive effects when used with antidiabetic medications. Seek medical advice before any use.nn

Allergies: avoid

Eucalyptus and tea tree oils share many constituents. If a patient is allergic to eucalyptus oil, cross-reactivity with other essential oils, including tea tree oil, is possible. nnSome compounds, such as 1,8-cineole (eucalyptol), limonene, and beta-caryophyllene, are present in almost all essential oils and may explain the observation that many patients show cross-reactivity to more than one essential oil.nn

Children aged 2 to 4 years: avoid

Use in children between 2.5 and 4 years has not been established due to a lack of data.nn

Breastfeeding: avoid

Not enough data; avoid as a precaution.nn


Contraindications

Infant up to 30 months: contraindicated

Contraindicated for children under 30 months because preparations containing 1,8-cineole, like other essential oils, may induce laryngospasm.nn

Pregnancy: contraindicated

Eucalyptus oil is not indicated for pregnant women.nn