Saw palmetto: benefits, dosage, contraindications
Other name(s)
Saw palmetto, Sabal
Scientific name(s)
Serenoa repens
Family or group:
Plants
Active ingredients:
Linoleic acid
Alpha-linolenic acid
Beta-sitosterol
Indications
Scoring methodology
EFSA approval.
Hair loss ✪✪✪✪✪
Preliminary clinical research shows that a combination of 200 mg saw palmetto extract and 50 mg beta-sitosterol taken twice daily improves subjective scores of hair quantity and quality in men with androgenetic alopecia. However, other clinical research shows that taking a saw palmetto extract at 320 mg per day for 24 months is less effective at improving hair growth in men with androgenetic alopecia than taking finasteride at 1 mg per day. nnSome earlier clinical research shows that saw palmetto lotion applied twice daily for 50 weeks improves hair density by 27% in men and women with androgenetic alopecia. However, it is not clear whether saw palmetto produced a statistically significant improvement compared with placebo.nnnnnn
Posologie
Synergies
EFFECT OF GELATIN-CYSTINE AND SERENOA REPENS EXTRACT ON FREE RADICALS LEVEL AND HAIR GROWTH nn
A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-alpha-reductase in the Treatment of Androgenetic Alopecia
Benign prostatic hyperplasia ✪✪✪✪✪
There are many clinical studies on this subject; the smaller and shorter ones reported some slight to moderate improvements in urinary symptoms such as frequent urination, painful urination, urgency, and perineal heaviness. Some studies also show that saw palmetto decreases nocturia (the need to urinate at night), improves urinary flow, and reduces residual urine volume in patients with benign prostatic hyperplasia. nnHowever, larger and longer trials found no effect. The most recent Cochrane meta-analysis also found no effect. Research results remain inconsistent. This may be due to different study methodologies, patient populations, symptom measurement methods, and the saw palmetto products used in the studies. nnMost clinical studies, including those with positive and negative results, used liposterolic extracts of saw palmetto berries containing about 80% to 90% free fatty acids. nn
Posologie
Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial.
[Efficacy of Pretreatment With Serenoa Repens on Bleeding Associated With Transurethral Resection of Prostate]
Serenoa Repens (Permixon®) Reduces Intra- And Postoperative Complications of Surgical Treatments of Benign Prostatic Hyperplasia
Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial.
Serenoa repens monotherapy for benign prostatic hyperplasia (BPH): an updated Cochrane systematic review.
Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial.
Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia.
E/S/C/O/P: 2nd Edition of the ESCOP Monographs
Observational database Serenoa repens (DOSSER): overview, analysis and results. A multicenter SIUrO (Italian Society of Oncological Urology) project.
Effects of Pumpkin Seed Oil and Saw Palmetto Oil in Korean Men With Symptomatic Benign Prostatic Hyperplasia
Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms
Effects of Short-Term Dutasteride and Serenoa Repens on Perioperative Bleeding and Microvessel Density in Patients Undergoing Transurethral Resection of the Prostate
Prostatitis ✪✪✪✪✪
Saw palmetto may improve prostatitis symptoms compared with no treatment in patients with nonbacterial prostatitis. Other preliminary clinical evidence suggests that daily intake of saw palmetto extract for eight weeks, in addition to prulifloxacin at 600 mg per day for 15 days, reduces pain and urinary symptoms more significantly than prulifloxacin alone in patients with bacterial prostatitis. However, other preliminary clinical research suggests that 325 mg saw palmetto taken orally for one year does not significantly improve nonbacterial prostatitis and chronic pelvic pain syndrome compared with treatment with finasteride 5 mg. Interestingly, preliminary clinical research shows that taking a complex of saw palmetto, selenium, and lycopene for 8 weeks significantly improves symptoms and peak urinary flow in patients with chronic prostatitis and/or chronic pelvic pain syndrome compared with pretreatment. However, these effects were less pronounced in patients treated with saw palmetto alone, indicating that saw palmetto may not be the only active component of this combination.
Posologie
Synergies
[Efficiency and Safety of prostamol-Uno in Patients With Chronic Abacterial Prostatitis]
A Prospective, 1-year Trial Using Saw Palmetto Versus Finasteride in the Treatment of Category III Prostatitis/Chronic Pelvic Pain Syndrome
E/S/C/O/P: 2nd Edition of the ESCOP Monographs
European Union herbal monograph on Serenoa repens (W. Bartram) Small, fructus
Serenoa Repens Associated With Urtica Dioica (ProstaMEV) and Curcumin and Quercetin (FlogMEV) Extracts Are Able to Improve the Efficacy of Prulifloxacin in Bacterial Prostatitis Patients: Results From a Prospective Randomized Study
Serenoa Repens Extract in Addition to Quinolones in the Treatment of Chronic Bacterial Prostatitis: Preliminary Results of a Long-Term Observational Study
Properties
Antiandrogenic




Saw palmetto has antiandrogenic, antiproliferative, and anti-inflammatory properties that may be responsible for improving the symptoms of benign prostatic hyperplasia (BPH). Monitoring 5-alpha-reductase and dihydrotestosterone (DHT) is crucial because they play an important role in certain health conditions. 5-alpha-reductase is an enzyme that converts testosterone into DHT, a more potent form of testosterone. Elevated DHT levels are associated with problems such as benign prostatic hyperplasia (BPH) and androgenic alopecia Saw palmetto appears to noncompetitively inhibit types 1 and 2 5-alpha-reductase and prevent the conversion of testosterone to dihydrotestosterone (DHT) in vitro, which could contribute to slowing prostate growth. However, 5-alpha-reductase levels in prostatic tissue and serum testosterone, DHT, and PSA are not significantly reduced by saw palmetto in vivo. Inhibition of 5-alpha-reductase and prevention of the conversion of testosterone to DHT may also contribute to saw palmetto's activity in androgenic alopecia. It is suggested that this condition involves increased sensitivity of hair follicles to DHT, reducing their growth phase and size.
Usages associés
Anticancer




In laboratory studies, saw palmetto extract (Serenoa repens) has shown potential to fight cancer. It appears to inhibit an enzyme (urokinase-type plasminogen activator) associated with the spread of cancer cells in urological cancers. In addition, saw palmetto has demonstrated inhibitory effects on the growth and/or induction of cell death in several types of cancer cells, including various cancers of the prostate, breast, kidney, bladder, colon, and lung. These effects vary depending on the dose of extract used.
Anti-inflammatory




Inflammatory mediators appear to contribute to the etiology of BPH. In men with benign prostatic hyperplasia (BPH), a saw palmetto extract appears to decrease tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta, which are markers of inflammation in prostate tissue. Laboratory results suggest that saw palmetto inhibits lipoxygenase and cyclooxygenase (COX), which are involved in inflammation. In addition, animal research suggests that saw palmetto inhibits the accumulation of mast cells in the prostate.
Usages associés
Hormonal metabolism




Some animal research findings suggest that saw palmetto fruit extract has estrogenic activity due to its relatively high concentration of beta-sitosterol. However, human research results suggest that the extract exhibits anti-estrogenic activity in the prostate tissue of men with benign prostatic hyperplasia.
Safe dosage
Adults 18 years and older: 160 mg - 320 mg
Long-term use is possible. If symptoms persist while using saw palmetto, consult a doctor or a qualified healthcare professional. Symptoms: fever, spasms or blood in the urine, painful urination or urinary retention.
Interactions
Médicaments
Warfarin: minor interaction
A few suspected cases of interactions with warfarin have been reported. Increased INR values have been described. If you are taking an anticoagulant such as warfarin (Coumadin), the results of your prothrombin time test will be expressed as a ratio called the international normalized ratio (INR).
Oral contraceptives: moderate interaction
Saw palmetto may have anti-estrogenic effects. Its use could interfere with contraceptive medications.
Precautions
Children up to 18 years: avoid
Avoid due to lack of data.
Liver impairment: avoid
In cases of liver disorders, saw palmetto is not recommended.
Contraindications
Pregnant women: contraindicated
Saw palmetto has hormonal activity.
Breastfeeding women: contraindicated
Saw palmetto has hormonal activity.
Topical, oral: fruit
200 - 320 mg
2 - years
