Amylase: benefits, dosage, contraindications

Mis à jour le 8 November 2025

Enzymes are among the most important products obtained for human needs from plant and microbial sources. Amylases are glycosidases that catalyze the hydrolysis of the glycosidic bond in starch to generate smaller sugars. Amylase can be derived from several sources, such as plants, animals and microorganisms. The amylase enzyme family has been well characterized by the study of various microorganisms. Amylases are extracellular enzymes and are classified into three subtypes: - α-amylase - β-amylase - γ-amylase Amylase enzymes are also produced by the pancreas and the salivary glands. They help break down starch carbohydrates into sugars such as glucose and maltose so they can be easily absorbed by the body. Clinical applications include: - Acts on starch, glycogen and related oligosaccharides. - In combination with other enzymes, as digestive aids. - As an anti-inflammatory. - In the treatment of exocrine pancreatic insufficiency, amylaceous dyspepsia and cystic fibrosis.

Family or group:

Enzymes

Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.

One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.

Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.

No clinical studies to date that can demonstrate the indication.

Digestive disorders
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Amylase plays an essential role in the digestion of complex carbohydrates. It primarily acts by breaking down starch into maltose. Produced by the salivary glands and the pancreatic glands, salivary amylase initiates digestion in the mouth, particularly of starches, carbohydrates, and sugars. The pancreatic form continues this process. Amylase facilitates the digestion of complex sugars by cleaving polysaccharides. Also present in some foods, it can be measured in the blood and urine. An increase in its level may indicate pancreatic or kidney disorders and may be associated with abdominal pain.

Posologie

By mouth

3000 - 15000 DU

Clinical applications of amylase: Novel perspectives

Type 2 diabetes
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The use of amylase in the context of diabetes is based on its role in the digestion of complex carbohydrates. By helping to break down starch into simpler sugars, amylase may facilitate better management of blood glucose levels, a critical aspect for people with diabetes. Furthermore, individuals with low amylase levels may be more likely to develop complications related to glucose metabolism. This imbalance can potentially lead to insulin resistance and type 2 diabetes. Supplementing with amylase could therefore support the digestive process, particularly in individuals with insufficient secretion of this enzyme, thereby improving blood glucose regulation. This approach is part of a comprehensive diabetes control strategy, where a low glycemic index diet and medical monitoring remain essential.

Posologie

By mouth

3000 - 15000 DU

Clinical applications of amylase: Novel perspectives

Properties

Safe dosage

Adult: 3000 DU - 15000 DU

Dosages for adults for supplementation range from 3,000 DU to 15,000 DU or more. As a reminder, DU: Alpha-amylase Dextrinizing units. 1 DU = 48 USP (United States Pharmacopeia units). In the case of enzymes, the key measure is the activity unit. There is no direct relationship between weight and activity units. Therefore, be wary of a product that lists enzymes only in mg.

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