Klamath algae: benefits, dosage, contraindications

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Klamath algae is a cyanobacterium of the species Aphanizomenon flosaquae (AFA). It is a blue-green algae species harvested in large lakes, particularly Upper Klamath Lake (Oregon, United States). Klamath is even richer in vitamins, minerals, and trace elements than its cousin spirulina, another microalga from the "blue-green" family, also considered one of the most nourishing. It contains phycocyanins and phenylethylamine (PEA), a precursor to neurotransmitters known as the "love hormone." Klamath algae is also a source of vitamin B12; however — according to some studies — it may be inactive. Klamath is particularly suited to recovery periods after competition or injury. It promotes relaxation and cell regeneration.

Other name(s) 

Klamath, Aphanizomenon

Scientific name(s)

Aphanizomenon flosaquae (AFA)

Family or group: 

Superfood, aquatic organisms

Active ingredients:

Phycocyanin

Vitamin K

Vitamin A

Vitamin B12

Vitamin C

Vitamin E


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Menopause
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A preliminary study suggests that taking Klamath algae reduces menopause-related anxiety and depression compared with placebo in menopausal women aged 50 to 60. The treatment has no effect on vasomotor symptoms or hormone levels.

Posologie

posologieOral administration

posologie1.6 - 5 g

duration8 - weeks

populationWomen, Seniors

formulationpowder, capsule


Immune support
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It has been shown that consumption of 1.5 g of AFA induces changes in the immune system involving mobilization of lymphocytes and monocytes. The study concluded that a rapid change in the circulation of immune cells without lymphocyte activation was observed, which suggests that AFA increases "alertness" of the immune system without directly stimulating it.

Posologie

posologieOral

posologie1.5 - 5 g

formulationpowder, capsule


Tissue regeneration
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Bone marrow-derived stem cells have the ability to migrate to sites of tissue injury and participate in tissue regeneration. It has been shown that the number of circulating stem cells is a key parameter in this process. Therefore, stimulating the mobilization of bone marrow stem cells can accelerate tissue regeneration. It has been shown that Klamath can stimulate the mobilization of bone marrow stem cells. Indeed, in vivo studies have shown that an extract of Aphanizomenon flos-aquae (AFA) triggers the mobilization of CD34+ stem cells from the bone marrow.

Posologie

posologieOral

posologie3 - 5 g

formulationpowder, capsule


Detoxification
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Due to phycocyanin C (a component of Klamath) being a ligand for certain heavy metals, Klamath algae may have a detoxifying effect.

Posologie

posologieOral

posologie4 - 5 g

formulationpowder, capsule


Vegetarian diet
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A study showed that oral intake of a Klamath-based mixture for 3 months by subjects following a vegetarian diet improved their vitamin B12 status.

Posologie

posologieOral

posologie1.5 - 5 g

formulationpowder, capsule


Emotional balance
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Klamath has a revitalizing effect on the body. It is highly concentrated in phenylethylamines (PEA), molecules that act on mood, joy, and emotional well-being; Klamath algae play an important role in the transmission of norepinephrine and dopamine in the brain. It acts as a natural antidepressant and would therefore promote relaxation and improved mood.

Posologie

posologieOral

posologie4 - 5 g

formulationpowder, capsule


Healthy aging
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The 'Klamath' algae regenerates nerve cells and could slow signs of aging. It may act on bone marrow stem cells and may facilitate their migration to organs. Klamath may help protect neurons against Aβ peptide-induced neurotoxicity, as demonstrated by an in vitro study. This neuroprotective effect may help in the fight against Alzheimer's disease.

Posologie

posologieOral

posologie1 - 5 g

populationSeniors

formulationpowder, capsule


Properties


Immunomodulatory

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The polysaccharides found in large amounts in Klamath algae have immunomodulatory properties; they activate lymphocytes and help fight toxins by eliminating them quickly.

Usages associés

Immune support

Anti-inflammatory

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The algae's blue pigment contains phycocyanin, an active compound effective against inflammation.


Antioxidant

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The antioxidant effects of Klamath may be due to its component, C-phycocyanin. Animal and in vitro studies show that C-phycocyanin has antioxidant activity and scavenges free radicals


Anti-aging

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Klamath algae can regenerate nerve cells and may slow signs of aging. It may act on bone marrow stem cells and facilitate their migration to organs. Stem cells are the original form of specialized cells. For example, stem cells in bone underlie the renewal of cells in the immune and blood systems.

Usages associés

Tissue regeneration, healthy aging

Neurological

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Highly concentrated in phenylethylamines (PEA), molecules that influence mood, joy and emotional well-being, Klamath algae play an important role in the transmission of norepinephrine and dopamine in the brain. Consuming this food helps maintain calm and serenity and can help prevent depression.

Usages associés

Menopause, Emotional balance

Remineralizing

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Klamath is a rich source of nutrients, particularly minerals such as iron, manganese, zinc, sodium, potassium, phosphorus, calcium, magnesium, copper, selenium and chromium.

Usages associés

Vegetarian diet


Safe dosage

Adults 18 years and older: 1 g - 5 g (powder)

Some species of blue-green algae contain toxins that are harmful to the body. Indeed, they can be contaminated by the microcystin-producing species Microcystis aeruginosa, particularly when they are cultivated and harvested in uncontrolled locations, such as open lakes. Microcystins irreversibly inhibit protein phosphatases, resulting in acute hepatotoxic effects, liver failure, as well as chronic neurotoxic and carcinogenic effects. The World Health Organization (WHO) has set a daily exposure limit for microcystins of 0.04 µg/kg for adults. It is important to remain vigilant about the quality of Klamath-based dietary supplements. A daily dose of 3 to 5 grams is therefore recommended to obtain the therapeutic benefits of Klamath without experiencing adverse effects.


Interactions

Médicaments

Antidepressants: moderate interaction

Klamath algae contain phenylethylamine, a compound found in drugs used to treat depression, which may interact with antidepressants.

Antiplatelet agents/Anticoagulants: moderate interaction

Klamath algae contain significant amounts of vitamin K. This vitamin affects the blood clotting process; patients on anticoagulant therapy should avoid consuming foods high in vitamin K.

Immunosuppressants: moderate interaction

Theoretically, concurrent use of blue-green algae may interfere with immunosuppressive treatment since these algae can stimulate the immune system.


Precautions

Autoimmune diseases: use with caution

Klamath algae may stimulate immune function. Theoretically, it can exacerbate autoimmune diseases by stimulating disease activity. Patients with autoimmune diseases such as multiple sclerosis (MS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or others are advised to consume Klamath algae with caution.

Pregnant women: avoid

Avoid the use of Klamath algae due to a lack of reliable and sufficient information.

Breastfeeding women: avoid

Avoid the use of Klamath algae due to a lack of reliable and sufficient information.