White mulberry: benefits, dosage, contraindications

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The white mulberry, native to China, is a deciduous tree belonging to the Moraceae family. Known for its leaves that feed silkworms, this tree also has a long history of use in traditional Chinese, Japanese, and Korean medicine. In France, the earliest evidence of mulberry cultivation dates back to the Roman era, as shown by the discovery of mulberry seeds at various sites, mainly in southern France and the Mediterranean regions. Its fruits, leaves, and even its bark are rich in active components such as anthocyanins, flavonoids, and other polyphenols, which give it interesting medicinal properties. However, it is the leaves that are used therapeutically. In ancient societies, its leaves were used for their antioxidant and hypotensive properties, a use documented in several ancient texts and corroborated by contemporary analyses. Scientifically, studies highlight the antioxidant, anti-inflammatory, and antidiabetic properties of the white mulberry. These effects are attributed to key compounds such as 1-deoxynojirimycin and its derivatives found in the leaves. Thanks to these properties, white mulberry is a potential ally in the management of chronic diseases such as type 2 diabetes.

Scientific name(s)

Morus alba, Morus indica

Family or group: 

Plants

Active ingredients:

1-deoxynojirimycin


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Type 2 diabetes
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White mulberry shows variable efficacy for type 2 diabetes. A meta-analysis of 4 clinical studies (12 weeks) concluded a modest improvement in glucose tolerance without an impact on HbA1c, the glycated hemoglobin biological marker of long-term glycemic control. The doses studied range from 500 mg to 4.6 g per day, containing 5-18 mg of deoxynojirimycin.

Posologie

posologieOral: leaf

posologie500 mg

duration4 weeks

formulationstandardized extract


Metabolic syndrome
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White mulberry appears to have promising effects on certain aspects of metabolic syndrome, although the evidence is limited. A clinical study shows that supplementation with white mulberry extract (300 mg twice daily for 12 weeks) modestly improves lipid profiles, with a decrease in total cholesterol and LDL. In obese patients with prediabetes, a dose of 4.6 g three times daily for 12 weeks slightly reduces fasting blood glucose and HbA1c. Finally, in overweight adults following a hypocaloric diet, a white mulberry extract (800 mg three times daily for 90 days) leads to a significant weight loss of 10%.

Posologie

posologieOral: leaf

posologie600 mg

formulationstandardized extract


Properties


Hypoglycemic

full-leaffull-leaffull-leafempty-leaf

The white mulberry is recognized for its hypoglycemic properties, attributed mainly to the presence of bioactive compounds such as 1-deoxynojirimycin, a potent alpha-glucosidase inhibitor. This enzyme, involved in carbohydrate digestion, plays a key role in the release of glucose after a meal. By blocking its action, 1-deoxynojirimycin slows glucose absorption, reducing postprandial glycemic spikes.nnClinical studies support this effect. In addition, the antioxidant and anti-inflammatory compounds present in mulberry, such as flavonoids and anthocyanins, help reduce oxidative stress and the chronic inflammation associated with diabetes. This may also play a protective role against cardiovascular and neural complications related to the disease.nn

Usages associés

Type 2 diabetes

Metabolic

full-leaffull-leafempty-leafempty-leaf

Studies in mice fed a high-fat diet show that adding white mulberry fruit powder or polysaccharides extracted from the leaves significantly improves glucose tolerance. These compounds reduce body fat accumulation and weight gain while lowering LDL cholesterol levels in the blood. This dual effect on carbohydrate and lipid metabolism suggests an important role in preventing metabolic syndrome. White mulberry may help with weight management. Deoxynojirimycin inhibits alpha-glucosidase enzymes in the intestine, thereby delaying the absorption of polysaccharides and limiting postprandial glycemic spikes. In addition, leaf polysaccharides inhibit pancreatic lipase, the key enzyme in the absorption of dietary fats. This dual action slows the absorption of energy macronutrients and supports weight control.

Usages associés

Metabolic syndrome


Safe dosage

Adult: 500 mg - 3000 mg

White mulberry leaf powder or extract: generally administered at 0.5 to 1 g three times a day, for a maximum duration of 3 months. Standardized products: Leaf powder standardized to 1.5% 1-deoxynojirimycin.


Precautions

Pregnant women: avoid

Insufficient data to ensure safety; avoid use except under medical supervision.

Lactating woman: avoid

Insufficient data to ensure safety; avoid use except under medical supervision.