Orthosiphon: benefits, dosage, contraindications

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Orthosiphon, also known as "Java tea", is a medicinal plant belonging to the Lamiaceae family. Native to the tropical regions of Southeast Asia, such as Indonesia and Malaysia, it is widely cultivated for its therapeutic virtues and is also used in traditional medicinal preparations in Europe. The parts of orthosiphon that are used are mainly the dried leaves and upper stems. They are generally prepared as infusions, aqueous extracts, or hydroalcoholic extracts. These parts contain several bioactive compounds: - Lipophilic flavonoids: such as sinensetin, isosinensetin, and other flavonol glycosides, which are associated with antioxidant and anti-inflammatory properties. - Phenolic acids: like rosmarinic acid and other depsides, known for their antimicrobial and antioxidant effects. - Diterpenes: including pimarane, isopimarane and staminane, which contribute to its diuretic properties. - Triterpenes: and phytosterols such as β-sitosterol. - Essential oils: in small amounts (up to 0.7%), adding antimicrobial and anti-inflammatory effects. - Minerals: particularly a high potassium content, which supports its diuretic effects. Orthosiphon is mainly known for its use in the urinary disorders, but its active components also make it a promising plant for other indications that will be detailed later in the article.

Other name(s) 

Java tea

Scientific name(s)

Orthosiphon stamineus

Family or group: 

Plants


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Urinary tract infections, Urinary disorders
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Orthosiphon, known for its diuretic and antimicrobial properties, is traditionally used to treat urinary tract infections and relieve urinary disorders. Flavonoids, such as the sinensetin, increase diuresis and promote the elimination of pathogenic bacteria. An infusion made from dried leaves, consumed several times a day, helps reduce symptoms such as burning during urination and the sensation of incomplete voiding. Studies also show its beneficial effect on preventing recurrent urinary tract infections by increasing bladder emptying. The use of a combination of plants containing orthosiphon (90 mg/dry extract) in a standardized product was studied to treat urinary tract infections in 200 adult women. The recommended dose was two tablets, three times a day, for seven days. Results: a significant reduction in symptoms (ACSS score) from the first day and a lower need for antibiotics (15% versus 49% in the placebo group). This efficacy includes an improvement in dysuria and a reduction in suprapubic pain.

Posologie

posologieOral administration

posologie2 g

formulationinfusion, dry extract


Synergies


Water retention
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Thanks to its natural diuretic properties, orthosiphon stimulates the excretion of water and electrolytes, particularly sodium and potassium. This effect helps reduce edema caused by fluid retention, often associated with heart or kidney disorders. nnClinical trials have confirmed that doses of 2 to 3 g of dried leaves as an infusion increase diuresis without disturbing electrolyte balance, making it a safe alternative for treating water retention.nn

Posologie

posologieOral use

posologie2 g

formulationinfusion


High blood pressure
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By increasing renal sodium excretion, orthosiphon helps reduce blood volume and, consequently, blood pressure. Traditionally used as an infusion to treat mild hypertension, the plant also works thanks to its flavonoids and saponins, which have mild vasodilatory effects. nn

Posologie

posologieOral use

posologie2 g

formulationinfusion


Properties


Uricosuric effect

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Orthosiphon promotes the elimination of uric acid through the urine thanks to its action on the renal tubules. Its flavonoids, such as sinensetin, increase glomerular filtration and inhibit tubular reabsorption, thus reducing blood uric acid levels.

Usages associés

Urinary tract infections

Diuretic

full-leaffull-leaffull-leafempty-leaf

The phenolic compounds and flavonoids of orthosiphon stimulate diuresis by increasing urinary excretion of sodium and potassium. This action helps reduce fluid retention and improves kidney function.

Usages associés

Fluid retention, High blood pressure

Antimicrobial

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Orthosiphon shows antimicrobial activity against certain bacteria responsible for urinary tract infections, such as Escherichia coli. Its bioactive compounds, including diterpenes, disrupt the bacterial membrane and inhibit their growth.

Usages associés

Urinary tract infections

Anti-inflammatory

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The flavonoids and diterpenes of orthosiphon inhibit the production of pro-inflammatory mediators, such as prostaglandins and TNF-alpha. This action helps reduce acute and chronic inflammation.


Safe dosage

Adult: 2 g - 3 g (infusion)

For adults, it is recommended to prepare an infusion using 2 to 3 g of dried leaves of orthosiphon in 150 ml of water hot. This infusion can be consumed two to three times per day as needed.nn


Precautions

Pregnancy: avoid

No data available. In accordance with general medical practice, orthosiphon should not be used during pregnancy without medical advice.nn

Breastfeeding: avoid

No data available. In accordance with general medical practice, orthosiphon should not be used while breastfeeding without medical advice.