Phosphatidylserine: benefits, dosage, contraindications
Other name(s)
PS
Scientific name(s)
Phosphatidylserine
Family or group:
Fatty Acids
Active ingredients:
Phospholipids
Indications
Scoring methodology
EFSA approval.
Alzheimer's disease ✪✪✪✪✪
Phosphatidylserine appears to improve activities of daily living, verbal expression, and sociability in subjects with Alzheimer's disease, as well as a slight improvement in memory and concentration. nnPhosphatidylserine appears to be more effective in patients with less severe symptoms. In addition, it may lose its effectiveness with prolonged use. After 16 weeks of treatment, the progression of Alzheimer's disease appears to overcome any benefit from phosphatidylserine. nnA daily dose of 300 to 400 mg (divided into 2 or 3) for a maximum of 16 weeks has been used.nn
Posologie
Oral
300 - 400 mg
16 - weeks
Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats.
Double-blind crossover study of phosphatidylserine vs. placebo in patients with early Alzheimer's-type dementia
Effects of phosphatidylserine in Alzheimer's disease.
Effects of phosphatidylserine in age-associated memory impairment.
Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation.
Cognitive decline ✪✪✪✪✪
Phosphatidylserine levels in the brain decrease with age. Supplementation could thus improve memory and cognitive function in older adults. Indeed, clinical studies show that phosphatidylserine improves attention, alertness, verbal fluency, and memory in older adults with cognitive impairment. Phosphatidylserine also appears to minimize age-related loss of neuronal dendrites and atrophy of cholinergic neurons. In 2003, the United States Food and Drug Administration (FDA) determined that it would allow a qualified health claim stating that consumption of phosphatidylserine may reduce the risk of developing age-related cognitive decline. However, the FDA determined that there is very little scientific evidence to support this claim. A dose of 100 mg of bovine- or plant-derived phosphatidylserine was used three times daily for up to 6 months. In addition, 1 to 3 capsules per day of a specific product were used, containing soy-derived phosphatidylserine 100 mg/capsule, docosahexaenoic acid (DHA) 19.5 mg/capsule, and eicosapentaenoic acid (EPA) 6.5 mg/capsule, for 15 weeks.
Posologie
Oral administration
100 - 300 mg
12 weeks
Synergies
Letter Updating the Phosphatidylserine and Cognitive Function and Dementia Qualified Health Claim
The Effect of Soybean-Derived Phosphatidylserine on Cognitive Performance in Elderly With Subjective Memory Complaints: A Pilot Study
An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline
Dementia ✪✪✪✪✪
In 2003, the United States Food and Drug Administration (FDA) determined that it would allow a qualified health claim stating that consumption of phosphatidylserine may reduce the risk of dementia in elderly people. However, the FDA determined that there is very little scientific evidence to support this claim.
Posologie
By mouth
100 - 300 mg
Cognitive performance ✪✪✪✪✪
The main clinical application of phosphatidylserine (PS) is to correct disorders of mental functioning in middle-aged and elderly people. In several randomized, double-blind, placebo-controlled trials, PS improved memory, learning, word recall, and other cognitive functions.
Posologie
By mouth
100 - 300 mg
Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration
The Effect of Soybean-Derived Phosphatidylserine on Cognitive Performance in Elderly With Subjective Memory Complaints: A Pilot Study
Double-blind randomized controlled study of phosphatidylserine in senile demented patients
Depression ✪✪✪✪✪
In a small double-blind trial in women suffering from major depression, phosphatidylserine significantly improved symptoms of depression and anxiety as well as cognition, irritability, and sociability. A dose of 300 mg per day for 30 days was used.
Posologie
Oral administration
300 mg
30 - days
Stress ✪✪✪✪✪
Phosphatidylserine appears to improve the ability of healthy young subjects to cope with stress, whether physical or psychological. Indeed, one study showed that taking 300 mg/day of phosphatidylserine for 30 days reduces perceived stress in students during timed mental arithmetic tests. Another double-blind trial showed that taking a phospholipid complex containing 400 mg of phosphatidylserine and 500 mg of phosphatidic acid significantly reduces stress hormones (adrenocorticotropic hormone and cortisol) compared with placebo.
Posologie
Oral administration
300 - 400 mg
30 - days
Properties
Neurological
It is thought that patients with dementia or age-related memory disorders have structural or functional abnormalities of neuronal membranes that lead to changes in neurotransmitter function. In addition, people with cognitive impairment often show alterations in levels of acetylcholine, norepinephrine, and serotonin. nnThus, some researchers believe that abnormal neuronal function may be attributable to changes in the brain's lipid composition. Exogenous administration of phosphatidylserine is thought to normalize the brain's lipid content and restore neuronal function to normal. nnFurthermore, animal and human studies show that phosphatidylserine improves stress management via the hypothalamic-pituitary-adrenal (HPA) axis, as well as the diurnal rhythms of pituitary hormone secretion.nnOther findings in animals have indicated that phosphatidylserine has an overall trophic (restorative) effect in the brain.nn
Usages associés
Cognitive function
It is thought that patients with dementia or age-related memory disorders have structural or functional abnormalities of neuronal membranes that lead to changes in neurotransmitter function. In addition, people with cognitive dysfunction often show alterations in levels of acetylcholine, norepinephrine, and serotonin. nnThus, some researchers believe that abnormal neuronal function may be attributable to changes in the brain's lipid composition. Exogenous administration of phosphatidylserine is thought to normalize the brain's lipid content and restore neuronal function to normal. nnIn animal models, phosphatidylserine improves spatial memory and passive avoidance. nn
Usages associés
Safe dosage
Adults aged 18 years and older: 100 mg - 300 mg
After more than 16 years of use as a dietary supplement, phosphatidylserine has no evidence of drug interactions or adverse effects at doses up to 800 mg/day. The standard dosing recommendation is 100 mg taken with meals, one to three times per day.
Child aged 4 to 18 years: 200 mg - 300 mg
Phosphatidylserine has been used safely in children aged 4 to 18 years taking doses of 200 to 300 mg per day for up to 4 months, according to clinical research.
Interactions
Médicaments
Acetylcholinesterase inhibitors: moderate interaction
Phosphatidylserine is thought to increase acetylcholine levels. Theoretically, the combination of phosphatidylserine and acetylcholinesterase inhibitors could abnormally increase acetylcholine levels and cause cholinergic side effects. Acetylcholinesterase inhibitors include donepezil, tacrine, rivastigmine, and galantamine.
Anticholinergics: moderate interaction
Phosphatidylserine is thought to increase acetylcholine levels. Theoretically, concomitant use of anticholinergic drugs and phosphatidylserine could reduce the effectiveness of the anticholinergic agent. Some anticholinergic drugs include atropine, benztropine, biperiden, procyclidine, trihexyphenidyl, and others.
Cholinergics: moderate interaction
Phosphatidylserine is thought to increase acetylcholine levels. Theoretically, combining phosphatidylserine with cholinergic medications could excessively raise acetylcholine levels and potentially cause cholinergic side effects. Some cholinergic medications include bethanechol, echothiophate (phospholine iodide), edrophonium, neostigmine, physostigmine, and pyridostigmine.
Precautions
Pregnant women: avoid
Avoid use due to lack of sufficient reliable information.
Breastfeeding women: avoid
Avoid use due to lack of sufficient reliable information.
